Epigenetics: Development and Disease
Springer (Verlag)
978-94-017-7996-8 (ISBN)
This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies.
This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.
PART I: EPIGENETICS AND EVOLUTION.- 1.1 Chromatin Organization, Epigenetics and Differentiation: An evolutionary perspective.- 1.2 Secondary structures of the core histone N-terminal tails: their role in regulating chromatin structure.- 1.3 Megabase replication domains along the human genome: Relation to chromatin structure and genome organization.- 1.4 Role of DNA methyltransferases in epigenetic regulation in bacteria.- PART II: DEVELOPMENTAL EPIGENETICS.- 2.1 Metabolic aspects of epigenome: Coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module.- 2.2 Epigenetic regulation of male germ cell differentiation.- 2.3 Epigenetic Regulation of Skeletal Muscle Development and Differentiation.- 2.4 Small changes, big effects: chromatin goes aging.- 2.5 Homeotic gene regulation: A paradigm for epigenetic mechanisms underlying organismal development.- PART III: EPIGENETICS AND TRANSCRIPTION REGULATION.- 3.1 Basic mechanisms in RNA Polymerase I transcriptionof the ribosomal RNA genes.- 3.2 The RNA polymerase II transcriptional machinery and its epigenetic context.- 3.3RNA polymerase III transcriptions - regulated by chromatin structure and regulator of nuclear chromatin organization.- 3.4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in humans.- 3.5 Histone variants and Transcription regulation.- 3.6Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View.- 3.7 Chromatin structure and organization: the relation with gene expression during development and disease.- PART IV: EPIGENETICS AND DISEASE.- 4.1 Epigenetics and cancer: Development, Differentiation and Pathobiology.- 4.2 Epigenetic Regulation of Cancer Stem Cell Gene Expression.- 4.3 Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes.- 4.4 Epigenetic changes in inflammatory and autoimmune diseases.- 4.5 Epigenetic regulation of HIV-1 persistence and evolving strategies for virus eradication.- 4.6 Epigenetics in Parkinson’s and Alzheimer’s diseases.- 4.7 Cellular Redox, Epigenetics and Diseases.- PART V: UNDERSTANDING OF EPIGENETICS: A CHEMICAL BIOLOGY
APPROACH AND EPIGENETIC THERAPY.- 5.1 Stem cell plasticity in development and cancer: Epigenetic origin of cancer stem cells.- 5.2Histone acetylation as a therapeutic target- Implication of nanodelivery.- 5.3 DNA methylation and Cancer.- 5.4 Role of epigenetics in inflammation-associated diseases.- 5.5 Plasmodium falciparum: Epigenetic control of var gene regulation and disease.
| Erscheint lt. Verlag | 23.8.2016 |
|---|---|
| Reihe/Serie | Subcellular Biochemistry ; 61 |
| Zusatzinfo | XXVI, 689 p. |
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Schlagworte | Cancer and diabetes • chromatin dynamics • Epigenetic therapy • gene expression • Stem cell differentiation and development |
| ISBN-10 | 94-017-7996-1 / 9401779961 |
| ISBN-13 | 978-94-017-7996-8 / 9789401779968 |
| Zustand | Neuware |
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