Statistical Methods for Microarray Data Analysis

Methods and Protocols

Andrei Y. Yakovlev, Lev Klebanov, Daniel Gaile (Herausgeber)

Buch | Softcover

212 Seiten

2016 | Softcover reprint of the original 1st ed. 2013
Humana Press Inc. (Verlag)
978-1-4939-5079-9 (ISBN)

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Microarrays for simultaneous measurement of redundancy of RNA species are used in fundamental biology as well as in medical research. Statistically,a microarray may be considered as an observation of very high dimensionality equal to the number of expression levels measured on it. In Statistical Methods for Microarray Data Analysis: Methods and Protocols, expert researchers in the field detail many methods and techniques used to study microarrays, guiding the reader from microarray technology to statistical problems of specific multivariate data analysis. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, Statistical Methods for Microarray Data Analysis: Methods and Protocols aids scientists in continuing to study microarrays and the most current statistical methods.

What Statisticians Should Know About Microarray Gene Expression Technology.- Where Statistics and Molecular Microarray Experiments Biology Meet.- Multiple Hypothesis Testing: A Methodological Overview.- Gene Selection with the d-sequence Method.- Using of Normalizations for Gene Expression Analysis.- Constructing Multivariate Prognostic Gene Signatures with Censored Survival Data.- Clustering of Gene-Expression Data via Normal Mixture Models.- Network-based Analysis of Multivariate Gene Expression Data.- Genomic Outlier Detection in High-throughput Data Analysis.- Impact of Experimental Noise and Annotation Imprecision on Data Quality in Microarray Experiment.- Aggregation Effect in Microarray Data Analysis.- Test for Normality of the Gene Expression Data.

Erscheinungsdatum	19.08.2017
Reihe/Serie	Methods in Molecular Biology ; 972
Zusatzinfo	XI, 212 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Mathematik / Informatik ► Informatik ► Theorie / Studium
	Informatik ► Weitere Themen ► Bioinformatik
	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie
Schlagworte	clustering of the tissue samples • gene expression • genes • gene signatures • microarrays • normalization procedures • Oncogene • Prolegomena • RNA • Statistical Methods
ISBN-10	1-4939-5079-7 / 1493950797
ISBN-13	978-1-4939-5079-9 / 9781493950799
Zustand	Neuware