Multiparticulate Drug Delivery (eBook)
XII, 396 Seiten
Springer New York (Verlag)
978-1-4939-7012-4 (ISBN)
Ali Rajabi-Siahboomi is Vice President and Chief Scientific Officer at Colorcon Inc. He obtained his PhD in Pharmacy from University of Nottingham (UK). Dr. Rajabi-Siahboomi held various academic positions in Nottingham and Liverpool JM Universities (UK), before joining Colorcon. His main research interests are in the area of solid dosage form pharmaceutics and pharmaceutical technology with emphasis on oral drug delivery systems. He has published over 150 articles, book chapters, abstracts and patents.
Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery. The book will cover market trends, potential benefits and formulation challenges for various types of multiparticulate systems. Drug solubility, dose, chemistry and therapeutic indications as well as excipient suitability coupled with manufacturing methods will be fully covered. Key approaches for taste-masking, delayed release and extended release of multiparticulates systems are of significant interest, especially their in-vivo and in-vitro performance. In addition, the principles of scale-up, QbD, and regulatory aspects of common materials used in this technology will be explained, as well as recent advances in materials and equipment enabling robust, flexible and cost-effective manufacture. Case studies illustrating best practices will also make the book a valuable resource to pharmaceutical scientists in industry and academia.
Ali Rajabi-Siahboomi is Vice President and Chief Scientific Officer at Colorcon Inc. He obtained his PhD in Pharmacy from University of Nottingham (UK). Dr. Rajabi-Siahboomi held various academic positions in Nottingham and Liverpool JM Universities (UK), before joining Colorcon. His main research interests are in the area of solid dosage form pharmaceutics and pharmaceutical technology with emphasis on oral drug delivery systems. He has published over 150 articles, book chapters, abstracts and patents.
Overview of multiparticulates.- Characterization of inert pellets for drug layering.- The science and practice of extrusion-spheronization.- Fluid bed technology, process robustness and scale-up.- Solution and suspension drug layering on inert pellets.- Dry powder layering on pellets Mini-tabs; versatile multiparticulate options for oral drug delivery.- Science and practice of microencapsulation technology.- Use of multiparticulate systems for fixed dose combination drug delivery.- Dissolution testing consideration of multiparticulate system.- Taste masking of multiparticulate systems.- Multiparticulate systems for pediatrics.- Application of methacrylic acid copolymers polymers for oral multiparticulate drug delivery.- Ethylcellulose applications on multiparticulate dosage forms.- Multi-unit particulate systems (MUPS).- In-line particle size characterization of multipartuclate systems.- In-vivo characterization of multiparticulate systems.
| Erscheint lt. Verlag | 26.5.2017 |
|---|---|
| Reihe/Serie | Advances in Delivery Science and Technology | Advances in Delivery Science and Technology |
| Zusatzinfo | XII, 396 p. 156 illus., 100 illus. in color. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Chemie | |
| Technik | |
| Schlagworte | Dissolution • Drug Delivery • Multiparticulate • Pellets • Scale-up |
| ISBN-10 | 1-4939-7012-7 / 1493970127 |
| ISBN-13 | 978-1-4939-7012-4 / 9781493970124 |
| Haben Sie eine Frage zum Produkt? |
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