Viruses, Genes, and Cancer

Buch | Hardcover

XIII, 221 Seiten

2017 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-61803-6 (ISBN)

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This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes - such as oncogenes, proto-oncogenes, or tumor suppressor genes - in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.

Eric Hunter, PhD, is a Professor of Pathology and Laboratory Medicine and a Georgia Research Alliance Eminent Scholar, based in Atlanta, GA, USAKlaus Bister, PhD, is a Professor Emeritus of Biochemistry of University of Innsbruck, Austria, and a Professor Adjunct of The Scripps Research Institute, La Jolla, CA, USA

Exchange of Genetic Sequences Between Viruses and Host.- Virus-Host Gene Interactions that Define HIV Disease Progression.- Sequencing the Biology of Entry: The Retroviral env Gene.- Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases.- MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.- Oncogenic Roles of the PI3K/AKT/mTOR Axis.- MicroRNAs and Cancer.- The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the P53 Gene.

Erscheinungsdatum	14.09.2017
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XIII, 221 p.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	510 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Biomedical and Life Sciences • Cancer Research • Medical microbiology & virology • Medical microbiology & virology • Medical Research • microRNA • mTOR • Myc • Oncogenic signaling • Oncology • P13 kinase • P53 gene • PI3 kinase • RAF • tumor suppressors • Virology • Virus-host cell interactions • Virus-host dene interactions
ISBN-10	3-319-61803-2 / 3319618032
ISBN-13	978-3-319-61803-6 / 9783319618036
Zustand	Neuware