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Engineering of Halogenases towards Synthetic Applications

Increasing the Thermostability and Investigations on a Marine Brominase Bmp5

Hannah Minges (Autor)

Buch | Softcover

XII, 116 Seiten

2017 | 1st ed. 2017
Springer Fachmedien Wiesbaden GmbH (Verlag)
978-3-658-18409-4 (ISBN)

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Hannah Minges focuses on the investigation of two different FAD-dependent halogenases in order to analyze and improve their applicability for chemoenzymatic approaches in chemistry. Owing to beneficial features, like high selectivity and benign reaction conditions, nature's toolkit for halogenation provides several advantages, whereas conventional chemical strategies require hazardous reagents and suffer from low selectivity. Therefore, enzymatic halogenation arises as promising alternative in the synthesis of valuable chemicals. One project focuses on the generation of a thermostable variant of the tryptophan halogenase Thal by means of directed evolution. The second project deals with the investigation of the marine halogenase Bmp5. This enzyme is of synthetic interest because it preferably introduces bromine into phenol compounds, whereas chlorination cannot take place.

Hannah Minges, a Ph.D student at Bielefeld University, works on the optimization of tryptophan halogenases by means of directed evolution.

Halogenating Enzymes.- Identification of a Thermostable Thal Variant by Directed Evolution.- Establishment of the Brominase Bmp5 for Synthetic Application.

Erscheinungsdatum	07.06.2017
Reihe/Serie	BestMasters
Zusatzinfo	XII, 116 p. 46 illus., 9 illus. in color.
Verlagsort	Wiesbaden
Sprache	englisch
Maße	148 x 210 mm
Gewicht	178 g
Themenwelt	Naturwissenschaften ► Biologie ► Ökologie / Naturschutz
	Naturwissenschaften ► Chemie ► Organische Chemie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
Schlagworte	Biocatalysis • Bmp5 • catalysis • Chemistry • Chemistry and Materials Science • directed evolution • Enzyme • Green chemistry • Organic Chemistry • sustainability • Thal
ISBN-10	3-658-18409-4 / 3658184094
ISBN-13	978-3-658-18409-4 / 9783658184094
Zustand	Neuware