Computational Methods for Processing and Analysis of Biological Pathways (eBook)

Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos (Autoren)

eBook Download: PDF

2017 | 1st ed. 2017
VIII, 87 Seiten
Springer International Publishing (Verlag)
978-3-319-53868-6 (ISBN)

Infos

This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.

Anastasios Bezerianos is a Professor at the Medical School of Patras University, Greece. He is also a Senior Principal Research Fellow at the Singapore Institute for Neurotechnology (SINAPSE) within the Centre for Life Sciences (CeLS), a Research Professor in the Department of Electrical and Computer Engineering (ECE), and a member of the Faculty of NUS Graduate School (NGS) for Integrative Sciences and Engineering at the National University of Singapore (NUS).

Andrei Dragomir is a Research Assistant Professor at the Department of Biomedical Engineering of the University of Houston, TX, USA.

Panos Balomenos is a PhD Candidate at the Computer Engineering and Informatics Department of the University of Patras, Greece.

Inhalt

Introduction

Networks and Pathways in Systems Pharmacology

Time Varying Methods for Pathway and Sub-Pathway Analysis

Identification of Differentially Expressed Pathways and Sub-Pathways

Produkt-Details

• Erscheint lt. Verlag: 9.3.2017
• Reihe/Serie: SpringerBriefs in Computer Science
• Reihe/Serie: SpringerBriefs in Computer Science
• Zusatzinfo: VIII, 87 p. 11 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Mathematik / Informatik ► Informatik
• Themenwelt: Naturwissenschaften ► Biologie
• Schlagworte: Bioinformatics • graph theory • network biology • pathway analysis • systems biology
• ISBN-10: 3-319-53868-3 / 3319538683
• ISBN-13: 978-3-319-53868-6 / 9783319538686