Drug Safety Evaluation
Humana Press Inc. (Verlag)
978-1-4939-7170-1 (ISBN)
Authoritative and practical, Drug Safety Evaluation: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Nonclinical Development of Combination Drugs.- Juvenile Non-Clinical Safety Studies in Support of Pediatric Drug Development.- Procedures of Necropsy and Tissue Sampling.- Tissue Sampling and Processing for Histopathology Evaluation.- Principles and Methods of Immunohistochemistry.- Applications of Mass Spectrometry Imaging for Safety Evaluation.- In vivo rat T-lymphocyte Pig-a assay: detection and expansion of cells deficient in the GPI-anchored CD48 surface marker for analysis of mutation in the endogenous Pig-a gene.- Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids.- The Use of Bacterial Repair Endonucleases in the Comet Assay.- Automated Patch-Clamp methods for the hERG Cardiac Potassium Channel.- Impedance Measurement in Induced Pluripotent Stem Cell Derived Cardiomyocytes.- Target Safety Assessment: Strategies and Resources.- NMR and MS Methods for Metabolomics.- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR.- Statistical Analysis of Quantitative RT-PCR Results.- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes.- FETAX Assay for Evaluation of Developmental Toxicity.- Evaluation of Embryotoxicity Using the Zebrafish Model.- Absolute Quantification of Toxicological Biomarkers via Mass Spectrometry.- Next-Generation Sequencing to investigate urinary microRNAs from Macaca fascicularis (Cynomolgus Monkey).- Quantitative RT-PCR for MicroRNAs in Biofluids.- Chromogenic In Situ Hybridization Methods for microRNA Biomarker Monitoring of Drug Safety and Efficacy.- Urine Exosome Isolation and Characterization.
Erscheinungsdatum | 18.08.2017 |
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Reihe/Serie | Methods in Molecular Biology ; 1641 |
Zusatzinfo | 28 Illustrations, color; 30 Illustrations, black and white; XI, 427 p. 58 illus., 28 illus. in color. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pharmazie | |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
Schlagworte | histopathology evaluation • immunohistochemistry • investigative toxicology • mass spectrometry imaging • necropsy • patch-clamp procedures • Pig-a mutation |
ISBN-10 | 1-4939-7170-0 / 1493971700 |
ISBN-13 | 978-1-4939-7170-1 / 9781493971701 |
Zustand | Neuware |
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