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Liver Regeneration and Carcinogenesis

Molecular and Cellular Mechanisms

(Autor)

Buch | Hardcover
402 Seiten
1995
Academic Press Inc (Verlag)
978-0-12-385355-4 (ISBN)
CHF 76,75 inkl. MwSt
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This study synthesizes current research into mechanisms of carcinogenesis and cell growth, using the liver as a model system to study these and other phenomena. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis and liver tumour therapy.
Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of researh disciplines. This book brings together current findings in a coherent manner, from a molecular point of view. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis, and liver tumor therapy. The contributors are pioneers and leaders in this field.

Liver Regeneration, Then and Now. Hepatocyte Growth Factor (HGF) and Its Receptor (MET) in Liver Regeneration, Neoplasia, And Disease. Structure and Functions of the HGF Receptor (C-Met). Expression and Function of Growth-Induced Genes During Liver Regeneration. Stem Cells and Hepatocarcinogenesis. Contributions of Hepadnavirus Research to Our Understanding of Hepatocarcinogenesis. Apoptosis and Hepatocarcinogenesis. Liver Tumor Promotion and the Suppression of P53-Dependant Cell Cycle Checkpoint Function. Mechanisms of Liver Tumor Promotion. Hypomethylation of DNA: A Epigenetic Mechanism that Can Facilitate the Aberrant Oncogene Expression Involved in Liver Carcinogenesis. Transgene-Based Strategies for Studying Liver Growth, Development and Cancer. Subject Index.

Erscheint lt. Verlag 27.9.1995
Verlagsort San Diego
Sprache englisch
Gewicht 760 g
Themenwelt Medizinische Fachgebiete Innere Medizin Hepatologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Naturwissenschaften Biologie Genetik / Molekularbiologie
ISBN-10 0-12-385355-9 / 0123853559
ISBN-13 978-0-12-385355-4 / 9780123853554
Zustand Neuware
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