Molecular Basis for Mitochondrial Signaling

Buch | Hardcover

XIV, 386 Seiten

2017 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-55537-9 (ISBN)

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This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.

From the Contents: Mitochondrial Calcium Signaling.- Systems approaches to mitochondrial calcium signaling.- The mitochondrial Calcium Uniporter: Molecular Composition And Physiological Role.- Molecular Mechanisms of Mitochondrial Ca2+ Uptake.- Ca2+ uniporter and male fertility.

Erscheinungsdatum	04.06.2017
Reihe/Serie	Biological and Medical Physics, Biomedical Engineering
Zusatzinfo	XIV, 386 p. 61 illus., 54 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	760 g
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
Themenwelt	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
Schlagworte	Apoptosis • Biophysics of membrane transport • Calcium Signaling • Cell Cycle Analysis • cellular metabolism • Ion channels and transporters • Mitochondria and disease • Mitochondria in apoptosis • Mitochondrial metabolism • Proapoptotic proteins
ISBN-10	3-319-55537-5 / 3319555375
ISBN-13	978-3-319-55537-9 / 9783319555379
Zustand	Neuware