Vascularization for Tissue Engineering and Regenerative Medicine

Wolfgang Holnthoner, Andrea Banfi, James Kirkpatrick, Heinz Redl (Herausgeber)

Buch | Hardcover

XXI, 565 Seiten

2021 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-319-54584-4 (ISBN)

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This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.

Wolfgang Holnthoner is an endothelial cell biologist and heads the Endothelial Cell/Vascularization Group at LBI Trauma in Vienna. He gained expertise in angiogenesis as well as lymphangiogenesis research in Austria and in Finland. His research interests span basic aspects of vascular biology (especially lymphatic vessels) involving the new era of extracellular vesicles research but also translational topics with the focus on microvascularization of engineered tissues. Andrea Banfi directs the Cell and Gene Therapy research group at the University Hospital of Basel, Switzerland. He previously worked in Genova (Italy) and Stanford (CA, USA). His research focuses on: 1) understanding the basic principles governing the growth of blood vessels, particularly the molecular crosstalk between endothelium, mural cells and inflammatory monocytes, in order to identify druggable targets for therapeutic vascular growth; and 2) translating these concepts into novel regenerative medicine approaches, particularly to generate vascularized tissue-engineered grafts and to treat ischemic diseases. Charles James Kirkpatrick is emeritus Professor of Pathology at the Johannes Gutenberg University Medical Center in Mainz, Germany, where he directed the Institute of Pathology from 1993 to 2015. He holds honorary and visiting professorships at universities in Sweden, China, Singapore, and Cuba and is a former President of both the German Society for Biomaterials (2001-2005) and the European Society for Biomaterials (ESB, 2002-2007). His principal research interests are in the fields of biomaterials in tissue engineering and regenerative medicine, with special focus on human co-culture systems to understand mechanisms of biomaterial interactions with human tissues. Heinz Redl has served as Director of the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (LBI Trauma), part of the AUVA Research Center, since 1998 and is the founder of Trauma Care Consult, a company intended to promote collaboration with industry. His goals are to improve the diagnostic and therapeutic options available to trauma patients, and to establish new national and international networks – as can be seen in the 2006 launch of the Austrian Cluster for Tissue Regeneration and subsequent creation of the European Institute of Excellence for Tissue Engineering and Regenerative Medicine (Expertissue), which he co-founded.

Angiogenesis induction.- Physical stimulation.- Shockwave.- HIF stabilisation.- Angiogenic factors.- Slow release.- Angiogenic cells.- Lymphogenesis induction.- (Pre)vascularisation.- Channels for vascularisation.- Additive manufacturing.- Mechanical molds.- Lost molds.- Decellularized vessel trees.- Microvascular approaches.- Cellular network formation.- Dual level approach.- Vascular grafts.

Erscheinungsdatum	03.06.2021
Reihe/Serie	Reference Series in Biomedical Engineering
Reihe/Serie	Tissue Engineering and Regeneration
Zusatzinfo	XXI, 565 p. 92 illus., 86 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	1037 g
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Herz- / Thorax- / Gefäßchirurgie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Technik ► Maschinenbau
Schlagworte	Angiogenic cells • biomaterials • biomedical engineering • Biotechnology • cellular biology (cytology) • Decellularized vessel trees • Engineering • Engineering: general • Lymphogenesis induction • Materials Science • Principles of angiogenesis induction • Regenerative Medicine/Tissue Engineering • Vascular grafts • vascular surgery
ISBN-10	3-319-54584-1 / 3319545841
ISBN-13	978-3-319-54584-4 / 9783319545844
Zustand	Neuware