Inflammation, Aging, and Oxidative Stress (eBook)
XIII, 405 Seiten
Springer International Publishing (Verlag)
978-3-319-33486-8 (ISBN)
The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer's disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson's disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging.
Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer's Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.
Arezoo Campbell received a B. A. in philosophy, a B. S. in biological sciences and a Ph.D. in environmental toxicology from the University of California, Irvine (UCI) in Irvine, California. She is currently an Associate Professor in the Department of Pharmaceutical Sciences at Western University of Health Sciences.
Stephen Bondy received an M. A. in biochemistry from Cambridge University, in Cambridge, England and his Ph.D. in neurochemistry from Birmingham University, in Birmingham, England. He subsequently held appointments at Columbia University, University of California Los Angeles, University of Colorado, and the National Institutes of Environmental Health Sciences. He is currently a Professor in the Center for Occupational and Environmental Medicine at the University of California, Irvine. His research focuses on identifying environmental factors which may accelerate brain aging, with emphasis on understanding the mechanisms that may underlie these events. In addition, Dr. Bondy is pursuing the development of therapeutic approaches with the potential to slow neurodegenerative processes.
Arezoo Campbell received a B. A. in philosophy, a B. S. in biological sciences and a Ph.D. in environmental toxicology from the University of California, Irvine (UCI) in Irvine, California. She is currently an Associate Professor in the Department of Pharmaceutical Sciences at Western University of Health Sciences. Dr. Campbell’s research emphasizes the means by which environmental exposures induce aberrant innate immune responses, which may accelerate the appearance of age-related neurodegenerative disease. Dr. Campbell also investigates the importance of inflammatory and oxidative stress in contributing to adverse changes within the brain.Stephen Bondy received an M. A. in biochemistry from Cambridge University, in Cambridge, England and his Ph.D. in neurochemistry from Birmingham University, in Birmingham, England. He subsequently held appointments at Columbia University, University of California Los Angeles, University of Colorado, and the National Institutes of Environmental Health Sciences. He is currently a Professor in the Center for Occupational and Environmental Medicine at the University of California, Irvine. His research focuses on identifying environmental factors which may accelerate brain aging, with emphasis on understanding the mechanisms that may underlie these events. In addition, Dr. Bondy is pursuing the development of therapeutic approaches with the potential to slow neurodegenerative processes.
Part I) Relation between adverse oxidant and inflammatory changes.- 1)Relationship between inflammatory and oxidative pathways in the disease process.- 2) Nitric oxide, the common denominator in oxidative and inflammatory events.- 3) Genomic profiling of the link between oxidative and inflammatory events.- 4) Environmental toxicants inflammation and oxidative stress.- Part II) Role of oxidative events in age-related diseases.- 5) Mitochondrial DNA deletions and oxidative stress.- 6) Oxidative stress and Alzheimer’s disease.- 7) Oxidative stress and Parkinson’s disease.- 8) Oxidative stress, cause or consequence of aging?.- 9) Oxidative events in intracellular signaling.- 10) Oxidative stress and drugs of abuse.- Part III) Role of inflammatory events in age-related diseases.- 11) Limitations of animal models of human inflammatory disease.- 12) Microglial activation in neurodegenerative diseases.- 13) Particle- induced inflammation and cardiovascular disease.- 14) Microglia and inflammation in Parkinson’s disease.- Part IV) Modulation of disease by anti-oxidant and anti-inflammatory agents.- 15) Alzheimer’s disease and anti-oxidant therapy.- 16) Antioxidant, and behavioral therapy in slowing brain aging .- 17) Treatment of age-related disease using micronutrients.- 18)Anti-inflammatory treatment in neurological disease.
| Erscheint lt. Verlag | 14.12.2016 |
|---|---|
| Reihe/Serie | Oxidative Stress in Applied Basic Research and Clinical Practice | Oxidative Stress in Applied Basic Research and Clinical Practice |
| Zusatzinfo | XIII, 405 p. 19 illus., 14 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Themenwelt | Studium ► Querschnittsbereiche ► Infektiologie / Immunologie |
| Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
| Schlagworte | age-related disease • Alzheimer's • Antioxidants • Metal toxicity • mitochondiral DNA • Parkinson's |
| ISBN-10 | 3-319-33486-7 / 3319334867 |
| ISBN-13 | 978-3-319-33486-8 / 9783319334868 |
| Haben Sie eine Frage zum Produkt? |
PDF (Wasserzeichen)Größe: 7,1 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich
