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Molecular Pathogenesis and Signal Transduction by Helicobacter pylori

Nicole Tegtmeyer, Steffen Backert (Herausgeber)

Buch | Hardcover

XXIV, 347 Seiten

2017 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-50519-0 (ISBN)

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This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori , which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike.

Dr. rer. nat. Nicole TegtmeyerProf. Dr. rer. nat. Steffen BackertChair of MicrobiologyFriedrich Alexander University Erlangen/NurembergDepartment of Biology, Division of MicrobiologyStaudtstr. 591058 ErlangenGermany

The human stomach in health and disease: infection strategies by Helicobacter pylori.- Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases.- Immune evasion strategies and persistence of Helicobacter pylori.- Recent advances in Helicobacter pylori replication: possible implications in adaptation to a pathogenic lifestyle and perspectives for drug design.- The Helicobacter pylori Methylome: Roles in Gene Regulation and Virulence.- Structural insights into Helicobacter pylori Cag protein interactions with host cell factors.- Gastric organoids: An emerging model system to study Helicobacter pylori pathogenesis.- DNA Transfer and Toll-Like Receptor Modulation by Helicobacter pylori.- Exploiting the gastric epithelial barrier: Helicobacter pylori's attack on tight and adherens junctions.- Helicobacter pylori-induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease.- Impact of the microbiota and gastric disease development by Helicobacter pylori.- Pathogenesis of gastric cancer: genetics and molecular classification.- Helicobacter pylori-mediated genetic instability and gastric carcinogenesis.- Helicobacter pylori and extragastric diseases.

Erscheinungsdatum	18.02.2017
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XXIV, 347 p. 33 illus., 31 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Viszeralchirurgie
	Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	bacterial virulence factors • Biomedical and Life Sciences • Cancer Research • Gastric acid secretion • Gastric cancer • Gastric disease • Gastric organoids • gastroenterology • Gastrointestinal disease • H. pylori • H. pylori infection • H. pylori virulence factors • Immune evasion concepts • Infection strategies • Medical Microbiology • Medical microbiology and virology • Medical Research • Oncology • Peptic Ulcer • Stomach Cancer
ISBN-10	3-319-50519-X / 331950519X
ISBN-13	978-3-319-50519-0 / 9783319505190
Zustand	Neuware