Alternatives for Dermal Toxicity Testing

Chantra Eskes, Erwin van Vliet, Howard I. Maibach (Herausgeber)

Buch | Hardcover

XX, 592 Seiten

2017 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-50351-6 (ISBN)

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This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.

Chantra Eskes, PhD, Eng, has around 20 years of experience in the development, optimization, and validation of alternative methods to animal testing. Her activities have contributed to the formal validation and regulatory acceptance of several test methods and to the development of a number of official international test guidelines. Dr. Eskes acts as a Nominated Expert and co-chair for the OECD in the areas of eye irritation/corrosion, skin irritation, skin corrosion, and skin sensitization. She is also President of the European Society of In Vitro Toxicology (ESTIV) and Executive Secretary of the Animal Cell Technology Industrial Platform (ACTIP). She is manager and consultant at SeCAM, a limited company that offers independent consultation and services on alternative methods for scientific, regulatory, and industrial tailored requirements. She is the editor, author, or co-author of more than 35 published scientific articles and book chapters and acts as a reviewer for sever al journals in the field of in vitro toxicology.

Introduction.- Concepts.- Skin irritation.- Skin corrosion.- Skin sensitization.- UV-induced effects (phototoxicity & photoallergy).- Skin genotoxicity.- Other exploratory areas of relevance.

Erscheinungsdatum	05.01.2018
Zusatzinfo	XX, 592 p. 92 illus., 61 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Alternatives to animal testing • Animal Models • Cosmetics • Dermatology • In vitro toxicology • Medicine • Medicine: general issues • pharmacology • Pharmacology/Toxicology • Regulatory testing • Safety testing • Zoology and animal sciences
ISBN-10	3-319-50351-0 / 3319503510
ISBN-13	978-3-319-50351-6 / 9783319503516
Zustand	Neuware