Fiber Toxicology
Academic Press Inc (Verlag)
978-0-12-735430-9 (ISBN)
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The known commercial uses of new mineral-fibre substitutes and non-asbestiform synthetics presents a potentially great health risk because most materials have not been tested for pathogenicity - "Fiber Toxicology" was written to help prevent a repeat of the asbestos dilemma. It examines the lessons learned from the toxicological study of asbestos and provides a framework for new toxicological studies on non-asbestos fibers. This book also introduces new state-of-the-art concepts and methods for evaluating the toxicology of various fibre-types on different pulmonary systems. It covers topics from the molecular biology to cell biology (in vitro) and from intraperitoneal to inhalation models. It also examines some of the most important controversies in fibre toxicology: "in vitro" versus "in vivo" and alternative methods of exposure (intraperitoneal) to physiological methods (inhalation). Finally, the proactive angle of this text is further enhanced with a chapter on carbon fibre toxicology - the only available lucid discussion of this emerging field.
The biological effects of fibres - a historical review and perspective, P. Kotin; introduction to fibre toxicology, C.L. Kennedy, Jr and D.P. Kelly; mammalian cell culture models for studying the toxicity of fibres, T.W. Hesterberg; bronchoalveolar lavage in the assessment of the cellular response to fibre exposure, K. Donaldson and G.M. Brown; the biological implications and limitations of the inhalation, intratracheal and intracoelomic routes of fibre administration, N.F. Johnson; mechanistic studies on the development of fibre-related pulmonary fibrosis, D.B. Warheit and S.H. Gavett; morphometric assessment of lung injury patterns following the inhalation of mineral fibres, K.E. Pinkerton; mechanisms of mesothelial cell injury, proliferation, and neoplasia induced by asbestos fibres, A.B. Kane; assessments of pulmonary toxicity following short-term exposures to inhaled fibres, D.B. Warheit; effects of fibres on the lung - an overload phenomenon?, G. Oberdorster; assessments of the biological effects of fibrous materials in experimental studies and related regulatory aspects. V. Vu and K. Dearfield; biophysical factors affecting fibre toxicity, M. Lippmann; fibre toxicology in man - lessons learned from analysis of the asbestos fibre content in human lung, A. Churg; toxicological effects of carbon fibre composite materials, D.L. Luchtel; mathematical models of fibre deposition in the lung, C.P. Yu and B. Asgharian; the possible role of surface chemistry in the toxicity of inhaled fibres, B. Fubine; testing the carcinogenicity of fibres in laboratory animals - possibilities, results and problems of extrapolation to humans, F. Pott; molecular approaches to understanding mechanisms of mesothelioma development, C. Walker.
| Zusatzinfo | index |
|---|---|
| Verlagsort | San Diego |
| Sprache | englisch |
| Maße | 160 x 236 mm |
| Gewicht | 930 g |
| Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Pathologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie | |
| Naturwissenschaften ► Chemie ► Technische Chemie | |
| Technik | |
| ISBN-10 | 0-12-735430-1 / 0127354301 |
| ISBN-13 | 978-0-12-735430-9 / 9780127354309 |
| Zustand | Neuware |
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