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The Actin Cytoskeleton and Bacterial Infection

Hans Georg Mannherz (Herausgeber)

Buch | Hardcover

X, 242 Seiten

2017 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-50046-1 (ISBN)

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This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for their own purposes. Bacterial factors either modify actin directly as the main component of this part of the cytoskeleton or functionally subvert regulatory or signalling proteins terminating at the actin cytoskeleton.
In short, this volume provides an overview of the various tricks bacteria have evolved to "act on actin" in order to hijack this essential host cell component for their own needs. As such, it will be of interest to scientists from many fields, as well as clinicians whose work involves infectious diseases.

Hans Georg MannherzRuhr-Universität BochumInstitut für AnatomieAbteilung für Anatomie und molekulare Embryologiee-mail: Hans.Mannherz@ruhr-uni-bochum.de

Actin structure and dynamics.- Influence of binary actin-depolymerizing toxins on the microtubule system.- ADP-ribosylation of actin by Photorhabdus luminescens TccC3 inhibits interaction with actin binding proteins essential for treadmilling.- Pathogenic mechanisms of actin cross-linking toxins - peeling away the layers.- New concepts on bacterial effectors targeting Rho GTPases.- Interaction of bacterial ADPribosyltransferases with actin.- Yersinia's ways to activate and inactivate actin rearrangements in host cells.- The role of formins in phagocytosis of Borrelia by macrophages.

Erscheinungsdatum	23.02.2017
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	X, 242 p.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Actin binding proteins • Actin cross-linking toxins • Actin structure • Bacterial actins • Bacterial actins • Bacterial ADPPribosyltransferases • Bacterial effectors • Bacterial manipulation • Biomedical and Life Sciences • Borrelia • Formins • Medical Microbiology • Medical microbiology and virology • Medical Research • pharmacology • Pharmacology/Toxicology • yersinia
ISBN-10	3-319-50046-5 / 3319500465
ISBN-13	978-3-319-50046-1 / 9783319500461
Zustand	Neuware