Classical Methods in Structure Elucidation of Natural Products
Helvetica Chimica Acta (Verlag)
978-3-906390-73-4 (ISBN)
The selection of the 25 representative examples is subjective and arbitrary, dictated by the author's pleasure in recovering fundamental milestones in organic chemistry, with each chapter devoted to one organic compound. The time period covered, however, is more precisely defined: 1860 represents the advent of structure theory, prior to which there was no conceptual framework to address the 'structure' of a compound. One hundred years later, 1960 approximately marks the change from classical structure elucidation to the era in which structure elucidation is mainly based on spectroscopic evidence and X-ray crystallography. Since the emphasis of this work is on classical structure elucidation, work performed later than 1960 is only considered in exceptional cases.
Rather than simply provide a history of structure elucidation of particular natural products, the author combines results from historic experiments to trace a line of evidence for those structures that are nowadays accepted as established. This line of evidence may follow the path put forward by the original contributors, yet in some cases the experimental facts have been combined to form another, hopefully shorter, line of evidence. As a result, readers are able to ascertain for themselves the 'facts behind the established structure assignments' of a number of important natural products.
Reinhard W. Hoffmann is Professor Emeriti of the University of Marburg. He studied chemistry at the Universität Bonn and received his Dr. rer. nat. in 1958 under the direction of Prof. B. Helferich. He spent two years as postdoctoral fellow at The Pennsylvania State University with Prof. G. W. Brindley and moved then to the Universität Heidelberg for another postdoctoral year with Prof. G. Wittig. In 1964 he obtained his habilitation and in 1967 he moved as lecturer to the Technische Hochschule Darmstadt and in 1970 to his present position as Professor of Organic Chemistry at the Universität Marburg. His research interests are new methods in stereoselective C-C-bond formation, their application in natural products synthesis and the stereochemistry of reactive organometallic compounds. More recent research activities concern combinatorial approaches to new catalysts and conformation design.
COMPOUNDS WITH ONLY OXYGEN FUNCTIONALITIES
Ascorbic Acid
Hinokitiol
Ascorbic Acid
Hinokitiol
Cantharidine
Camphor
Alpha--Terpineol
Lactaroviolin
Santonine
Estrone
Alpha--Tocopherol
COMPOUNDS WITH NITROGEN AND OXYGEN FUNCTIONALITIES
Pyridoxine
Muscarine
Lupinine
Lysergic Acid
Riboflavine
Cocaine
Quinine
Colchicine
Luciferin
Strychnine
COMPOUNDS WITH ADDITIONAL FUNCTIONALITIES
Biotin
Thiamine
Griseofulvin
COMPOUNDS WITHOUT HETEROATOM-FUNCTIONALITIES
Decacyclene
Carotene
CAN YOU DO IT YOURSELF?
Penicillin
| Erscheinungsdatum | 11.10.2017 |
|---|---|
| Sprache | englisch |
| Maße | 170 x 244 mm |
| Gewicht | 704 g |
| Themenwelt | Naturwissenschaften ► Chemie ► Analytische Chemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Schlagworte | Analytical Chemistry • Analytische Chemie • Chemie • Chemistry • Natural Products • Naturstoff • Naturstoffchemie • Organic Chemistry • Organische Chemie • Pharmaceutical & Medicinal Chemistry • Pharmazeutische u. Medizinische Chemie • Strukturanalyse • Strukturaufklärung |
| ISBN-10 | 3-906390-73-X / 390639073X |
| ISBN-13 | 978-3-906390-73-4 / 9783906390734 |
| Zustand | Neuware |
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