The Future of HIV-1 Therapeutics

Resistance Is Futile?

Bruce E. Torbett, David S. Goodsell, Douglas D. Richman (Herausgeber)

Buch | Softcover

X, 254 Seiten

2016 | 1. Softcover reprint of the original 1st ed. 2015
Springer International Publishing (Verlag)
978-3-319-37450-5 (ISBN)

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This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.

HIV Therapy Looking Towards the Future.- Computational challenges of structure-based approaches applied to HIV.- Nucleocapsid Protein: A Desirable Target For Future Therapies Against HIV-1.- HIV-1 integrase multimerization as a therapeutic target.- Targeting HIV transcription: The quest for a functional cure.- Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder.- HIV-1 Gag: An Emerging Target for Antiretroviral Therapy.- The Triple Threat of HIV-1 Protease Inhibitors.- Illustrations of the HIV Life Cycle.

"The book does a fantastic job of addressing new approaches to inhibit HIV-1. ... this is a useful book that can be used by researchers, HIV clinicians, and medicinal chemists interested in investigating new molecules for the treatment of HIV-1. It addresses novel areas that have no chemical entities that are FDA approved. There are no books that compete with this one." (Christopher J. Destache, Doody's Book Reviews, September, 2015)

"This book includes 8 comprehensive, heavily referenced chapters on antiretroviral drug development. ... a comprehensive, readable review of a subject that brings together 2 or more decades of molecular virology research and drug development. ... the chapters in this book are likely to be, for the next several years, highly useful and popular starting points for learning about new areas in HIV drug development." (Robert W. Shafer, Clinical Infectious Diseases, September, 2015)

Erscheinungsdatum	21.10.2016
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	X, 254 p.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	antibacterial drug resistance • Biomedical and Life Sciences • drug resistance • Fragment-based drug design • High-throughput virtual screening • HIV-1 antiretroviral treatment • HIV-1 drug resistance • HIV-1 illustrations • HIV-1 latency • HIV capsid • HIV Gag protein • HIV integrase protein • HIV matrix • HIV nucleocapsid protein • HIV protease • HIV reverse transcriptase protein • HIV stem-loop • HIV transcription • Human immunodeficiency virus • Infectious and contagious diseases • Infectious Diseases • LEDGF/p75 protein • Medical microbiology and virology • Medical Research • pharmacology • Rev protein • structure-based drug design • Tat/TAR/P-TEFb complex • Virology
ISBN-10	3-319-37450-8 / 3319374508
ISBN-13	978-3-319-37450-5 / 9783319374505
Zustand	Neuware