The Actin Cytoskeleton

Buch | Hardcover

XII, 352 Seiten

2017 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-46369-8 (ISBN)

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Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.

Functional significance of actin isoforms.- Assembly and maintenance of myofibrils in striated muscle cells.- Myosins: Domain organisation, motor properties, physiological roles and cellular functions.- Actin filament structures in migrating vertebrate cells.- Signalling pathways controlling cellular actin organization.- Actin-based endocytosis.- ADP-ribosylation and cross-linking of actin by bacterial protein toxins.- Common themes in cytoskeletal remodeling by intracellular bacterial effectors.- Viruses that exploit actin-based motility for their replication and spread.- Multiscale view of cytoskeletal mechanoregulation of cell and tissue polarity.- Molecular control of actin dynamics in vivo insights from Drosophila.- From cytoskeleton to gene expression - actin in the nucleus.

Erscheinungsdatum	10.02.2017
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	XII, 352 p. 60 illus., 30 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	actin-based pathogens • Actin Dynamics • Biomedical and Life Sciences • cell differentiation • cell physiology • cellular biology (cytology) • nuclear functions • pharmacology • Pharmacology/Toxicology • signalling pathways • toxin targets
ISBN-10	3-319-46369-1 / 3319463691
ISBN-13	978-3-319-46369-8 / 9783319463698
Zustand	Neuware