Issues in Clinical Epileptology: A View from the Bench
Springer (Verlag)
978-94-024-0789-1 (ISBN)
Preface.- Foreword.- Part I Seizures, epileptiform activities and regional localization.- How can we identify ictal and interictal abnormal activity?- How can we translate “epileptiform” activity in vitro into something that is clinically relevant?- What is the importance of abnormal “background” activity in seizure generation?- What is a seizure focus?- What is a seizure network? Very fast oscillations at the interface between normal and epileptic brain.- What is a seizure network? Long-range network consequences of focal seizures.- Is there any such thing as “generalized” epilepsy?- Part II Synaptic plasticity.- Are there really “epileptogenic” mechanisms or only corruptions of “normal” plasticity?- When and how do seizures kill neurons - and is cell death relevant to epileptogenesis?- How is homeostatic plasticity important in epilepsy?- Is plasticity of GABA ergic mechanisms relevant to epileptogenesis?- Do structural changes in GABA neurons give rise to the epileptic state?- Does mossy fiber sprouting give rise to the epileptic state?- Does brain inflammation mediate pathological outcomes in epilepsy?- Are changes in synaptic function that underlie hyperexcitability responsible for seizure activity?- Does epilepsy cause a reversion to immature function?- Are alterations in transmitter receptor and ion channel expression responsible for the epilepsies?- Part III Models and methods.- How do we assess the clinical relevance of models of mesial temporal lobe epilepsy?- How do we make models that are useful in understanding partial epilepsies?- What non-neuronal mechanisms should be studied to understand epileptic seizures?- What epilepsy comorbidities are important to model in the laboratory? Clinical perspectives.- Understanding epilepsy comorbidities: how can animal models help?- What new modeling approaches will help us identify promising drug treatments?- What are the arguments for and againstrational therapy for epilepsy?- How can advances in epilepsy genetics lead to better treatments and cures?- How might novel technologies such as optogenetics lead to better treatments in epilepsy?.
Erscheinungsdatum | 02.09.2016 |
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Reihe/Serie | Advances in Experimental Medicine and Biology ; 813 |
Zusatzinfo | 21 Illustrations, color; 29 Illustrations, black and white; XXI, 339 p. 50 illus., 21 illus. in color. |
Verlagsort | Dordrecht |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizinische Fachgebiete ► Chirurgie ► Neurochirurgie |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie | |
Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
Naturwissenschaften ► Biologie ► Humanbiologie | |
Naturwissenschaften ► Biologie ► Zoologie | |
Schlagworte | Translation |
ISBN-10 | 94-024-0789-8 / 9402407898 |
ISBN-13 | 978-94-024-0789-1 / 9789402407891 |
Zustand | Neuware |
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