Nanozymes: Next Wave of Artificial Enzymes (eBook)

xiaoyu wang, Wenjing Guo, Yihui Hu, Jiangjiexing Wu, Hui Wei (Autoren)

eBook Download: PDF

2016 | 1st ed. 2016
X, 127 Seiten
Springer Berlin (Verlag)
978-3-662-53068-9 (ISBN)

Infos

This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today's most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book's six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials' enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.

Xiaoyu Wang is a graduate student at the Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University. He received his B.S. degree from Nanjing Institute of Technology in 2014. In the same year he joined Professor Hui Wei's group. His research interests focus on nanozymes for biomedical and bioanalytical applications.

Wenjing Guo is a graduate student at the Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University. She received her B.S. degree from Nanjing University in 2014. In the same year she joined Professor Hui Wei's group. Her research interests focus on nanozymes for biomedical and bioanalytical applications.

Yihui Hu is a graduate student at the Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University. She received her B.S. degree from Hengyang Normal University in 2010 and her Master degree from Hunan University in 2013. In 2014, she joined Professor Hui Wei's group. Her research interests focus on bioanalytical and biomedical chemistry.

Jiangjiexing Wu is a research associate professor at the Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University. She received her B.S. degree and Ph.D. from Tianjin University in 2009 and 2014, respectively. In 2016, she joined Professor Hui Wei's group. Her research interests focus on DNA-directed approach to fabricate functional nanomaterials.

Hui Wei is a professor at the Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, China. He joined Nanjing University after his postdoctoral training with Professors Yi Lu and Shuming Nie, respectively. He received his B.S. from Nanjing University in 2003, where he carried out his undergraduate research with Professor Xinghua Xia. In the same year he joined Professor Erkang Wang's group at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, and received his Ph.D. in 2008. He has been admitted as a Fellow of Royal Society of Chemistry (FRSC). His research interests focus on functional bionanomaterials (including nanozymes), in vivo bioanalysis, in vitro diagnostics and precision medicine.

Inhalt

Preface 6
Contents 8
Abbreviations 10
1 Introduction to Nanozymes 12
Abstract 12
References 15
2 Carbon-Based Nanomaterials for Nanozymes 18
Abstract 18
2.1 Fullerene and Derivatives 18
2.1.1 Fullerene and Derivatives as Nuclease Mimics 19
2.1.2 Fullerene and Derivatives as SOD Mimics 20
2.1.3 Fullerene Derivatives as Peroxidase Mimics 23
2.2 Graphene and Derivatives 23
2.2.1 Graphene and Its Derivatives as Peroxidase Mimics 23
2.2.2 Decorated Graphene (or Its Derivatives) as Peroxidase Mimics 26
2.3 Carbon Nanotubes 31
2.3.1 Carbon Nanotubes as Peroxidase Mimics 31
2.3.2 Carbon Nanotubes as Other Enzyme Mimics 33
2.4 Other Carbon-Based Nanomaterials 35
2.4.1 Other Carbon Nanomaterials as Peroxidase Mimics 35
2.4.2 Other Carbon Nanomaterials as SOD Mimics 35
References 36
3 Metal-Based Nanomaterials for Nanozymes 41
Abstract 41
3.1 Metal Nanomaterials with Catalytic Monolayers (Type I) 41
3.1.1 AuNPs Protected by Alkanethiol with Catalytic Terminal Moieties 42
3.1.2 AuNPs Protected by Alkanethiol with Non-covalently Assembled Catalytic Moieties 47
3.1.3 AuNPs Protected by Thiolated Biomolecules 49
3.2 Metal Nanomaterials with Intrinsic Enzyme Mimicking Activities (Type II) 50
3.2.1 Metal Nanomaterials as GOx Mimics 50
3.2.2 Metal Nanomaterials as Multiple Enzyme Mimics 51
3.2.3 Applications 55
References 59
4 Metal Oxide-Based Nanomaterials for Nanozymes 66
Abstract 66
4.1 Cerium Oxide 66
4.1.1 Cerium Oxide as SOD Mimics 67
4.1.2 Cerium Oxide as Catalase Mimics 73
4.1.3 Cerium Oxide as Peroxidase Mimics 75
4.1.4 Cerium Oxide as Oxidase Mimics 75
4.1.5 Cerium Oxide as Other Mimics 76
4.2 Iron Oxide 77
4.2.1 Iron Oxide as Peroxidase Mimics 77
4.2.2 Iron Oxide as Other Enzyme Mimics 85
4.3 Other Metal Oxides 87
4.3.1 Vanadium Oxide as Enzyme Mimics 87
4.3.2 Cobalt Oxide as Enzyme Mimics 87
4.3.3 Copper Oxide as Enzyme Mimics 90
4.3.4 MoO3, TiO2, MnO2, RuO2 as Enzyme Mimics 90
References 91
5 Other Nanomaterials for Nanozymes 101
Abstract 101
5.1 Prussian Blue 101
5.2 Metal-Organic Frameworks 103
5.3 Metal Chalcogenides 105
5.4 Metal Hydroxides 105
5.5 Miscellaneous 106
References 106
6 Challenges and Perspectives 111
Abstract 111
References 113
Appendix 116
References 128

Produkt-Details

• Erscheint lt. Verlag: 27.7.2016
• Reihe/Serie: SpringerBriefs in Molecular Science
• Reihe/Serie: SpringerBriefs in Molecular Science
• Zusatzinfo: X, 127 p. 56 illus., 47 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik ► Bauwesen
• Themenwelt: Technik ► Maschinenbau
• Schlagworte: Artificial enzymes • Biomimetics • biosensing • Carbon-based nanomaterials • Enzyme mimics • Metal-based nanomaterials • Metal oxide-based nanomaterials • therapeutics • Translational Medicine
• ISBN-10: 3-662-53068-6 / 3662530686
• ISBN-13: 978-3-662-53068-9 / 9783662530689