Molecular Biology of Long Non-coding RNAs

Ahmad M. Khalil, Jeff Coller (Herausgeber)

Buch | Softcover

227 Seiten

2016 | Softcover reprint of the original 1st ed. 2013
Springer-Verlag New York Inc.
978-1-4939-4528-3 (ISBN)

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Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Preface.- Chromatin regulation by long non-coding RNAs.- Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs.- Roles of long non-coding RNAs in X-chromosome inactivation.- Roles of Long Non-Coding RNAs in Genomic Imprinting.- Dysregulation of long noncoding RNAs in human disease.- Functions of long non-coding RNAs in non-mammalian systems.- Emerging technologies to study long non-coding RNAs.- Long non coding RNAs and nuclear body formation and function.- Index.

Erscheinungsdatum	04.10.2016
Zusatzinfo	18 Illustrations, color; 10 Illustrations, black and white; X, 227 p. 28 illus., 18 illus. in color.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	dysregulation • gene regulation • lncRNAs • long non-coding RNAs
ISBN-10	1-4939-4528-9 / 1493945289
ISBN-13	978-1-4939-4528-3 / 9781493945283
Zustand	Neuware