Interleukin-10 in Health and Disease

Simon Fillatreau, Anne O'Garra (Herausgeber)

Buch | Softcover

VIII, 238 Seiten

2016 | 1. Softcover reprint of the original 1st ed. 2014
Springer Berlin (Verlag)
978-3-662-52405-3 (ISBN)

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This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies and IL-10 polymorphisms.- Control of intestinal inflammation by interleukin-10.- Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.- Interleukin-10-producing B cells and the regulation of immunity.- Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?- IL-10: achieving balance during persistent viral infection.- The role of microRNAs in the control and mechanism of action of IL-10.- The regulation of IL-10 expression.- The Molecular Basis of IL-10 Function: From Receptor Structure to the Onset of Signaling.- Role of IL-22 in microbial host defense.

Erscheinungsdatum	29.08.2016
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	VIII, 238 p. 16 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Anti-inflammatory cytokine • Biomedical and Life Sciences • cellular biology (cytology) • Counter-regulation of immunity • Cytokines and Growth Factors • IL-10 expression • Il-10 polymorphisms • immunology • Innate microbial recognition • interleukin-10 • Intestinal immunity • Maintenance of immune homeostasis • Medical Research • Molecular Biology • Molecular Medicine • TLR triggering • Tr1 cells • Viral IL-10 homologs
ISBN-10	3-662-52405-8 / 3662524058
ISBN-13	978-3-662-52405-3 / 9783662524053
Zustand	Neuware