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Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic

Interim Report

National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Inorganic Arsenic (Autoren)

Buch | Hardcover

127 Seiten

2013
National Academies Press (Verlag)
978-0-309-38767-5 (ISBN)

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The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) program develops toxicologic assessments of environmental contaminants. IRIS assessments provide hazard identification and dose-response assessment information. The information is then used in conjunction with exposure information to characterize risks to public health and may be used in risk-based decisionmaking, in regulatory actions, and for other risk-management purposes. Since the middle 1990s, EPA has been in the process of updating the IRIS assessment of inorganic arsenic. In response to a congressional mandate for an independent review of the IRIS assessment of inorganic arsenic, EPA requested that the National Research Council convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic is the report of the first phase of that study. This report evaluates critical scientific issues in assessing cancer and noncancer effects of oral exposure to inorganic arsenic and offers recommendations on how the issues could be addressed in EPA's IRIS assessment.

Table of Contents

Front Matter
Summary
1 Introduction
2 Exposure Considerations
3 IRIS Assessment Development Plans: Evidence Evaluation, Systematic Review, and Meta-analysis
4 Hazard Identification
5 Susceptibility Factors
7 DoseResponse Analysis
References
Appendix A--Biosketches of the Committee on Inorganic Arsenic
Appendix B--Workshop Agenda

1 Front Matter; 2 Summary; 3 1 Introduction; 4 2 Exposure Considerations; 5 3 IRIS Assessment Development Plans: Evidence Evaluation, Systematic Review, and Meta-analysis; 6 4 Hazard Identification; 7 5 Susceptibility Factors; 8 7 DoseResponse Analysis; 9 References; 10 Appendix A--Biosketches of the Committee on Inorganic Arsenic; 11 Appendix B--Workshop Agenda

Erscheint lt. Verlag	20.11.2013
Verlagsort	Washington
Sprache	englisch
Maße	216 x 279 mm
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
	Naturwissenschaften ► Biologie ► Ökologie / Naturschutz
	Sozialwissenschaften ► Politik / Verwaltung ► Staat / Verwaltung
ISBN-10	0-309-38767-1 / 0309387671
ISBN-13	978-0-309-38767-5 / 9780309387675
Zustand	Neuware