Adhesion G Protein-coupled Receptors

Molecular, Physiological and Pharmacological Principles in Health and Disease

Tobias Langenhan, Torsten Schöneberg (Herausgeber)

Buch | Hardcover

XIV, 403 Seiten

2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-41521-5 (ISBN)

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Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.

PART I. Molecular and Pharmacological Properties of Adhesion GPCRs:-Classification, Nomenclature and Structural Aspects of Adhesion GPCRs.- 7TM Domain Structure of Adhesion GPCRs.- Understanding the Structural Basis of Adhesion GPCR Functions.-Control of Adhesion GPCR Function Through Proteolytic Processing.-Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs.- Versatile Signaling Activity of Adhesion GPCRs.- Adhesion GPCR-Related Protein Networks.-The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans.- PART II: Adhesion GPCRs as Pharmakotargets in Organ Function and Development.- Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors.- Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration.- Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.-Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs.- Adhesion GPCR Function in Pulmonary Development and Disease.-Adhesion GPCRs as Modulators of Immune Cell Function.-Heart Development, Angiogenesis, and Blood-Brain Barrier Function is Modulated by Adhesion GPCRs.-Adhesion GPCRs in Tumorigenesis.

Erscheinungsdatum	04.12.2016
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	XIV, 403 p. 68 illus., 67 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Biomedical and Life Sciences • Cell Biology • Cell-Cell Interaction • Cell-matrix interaction • G protein-coupled receptors • Human genetics • Human Physiology • mechanoreception • medical biochemistry • Metabotropic pathways • Pharmacology/Toxicology
ISBN-10	3-319-41521-2 / 3319415212
ISBN-13	978-3-319-41521-5 / 9783319415215
Zustand	Neuware