Small-molecule Transcription Factor Inhibitors in Oncology

Khondaker Miraz Rahman, David Thurston (Herausgeber)

Buch | Hardcover

213 Seiten

2018
Royal Society of Chemistry (Verlag)
978-1-78262-145-4 (ISBN)

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This book highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors and is relevant for postgraduates, researchers and practitioners.

Oncogenic transcription factors are an increasingly important target for anticancer therapies. Inhibiting these transcription factors could allow tumour cells to be "reprogrammed", leading to apoptosis or differentiation from the malignant phenotype. As the use of kinase inhibitors is gradually declining, transcription factor inhibition is the next hot topic for oncology research and merits much attention. This book highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors. It also presents the evidence that this important protein class can be modulated in a number of ways to develop novel classes of therapeutic agents. The broad range of aspects covered by the book is noteworthy and renders it enormously valuable. This title serves as a unique reference book for postgraduates, academic researchers and practitioners working in the fields of biochemistry, biotechnology, cell and molecular biology and bio-inorganic chemistry.

Preface: Small Molecule Transcription Factor Inhibitors;

Synthetic Approaches and Challenges Towards Transcription Factor Inhibitors;

Computational Approaches in the Development of Small Molecule Transcription Factor Inhibitors;

Natural Products as Promising Leads Against Oncogenic Transcription Factors and Associated Signalling Pathways;

Pyrrolobenzodiazepines as Transcription Factor Inhibitors: An Overview;

Small Molecule Inhibitors of NF-kB and Their Therapeutic Potential in Leukaemia;

Targeting Signal Transducer and Activator of Transcription (STAT) 3 with Small Molecules;

Targeting Promoter G-Quadruplexes for Transcriptional Control

Erscheinungsdatum	22.06.2017
Reihe/Serie	Drug Discovery ; Volume 65
Verlagsort	Cambridge
Sprache	englisch
Maße	156 x 234 mm
Gewicht	487 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Chemie
ISBN-10	1-78262-145-8 / 1782621458
ISBN-13	978-1-78262-145-4 / 9781782621454
Zustand	Neuware