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Inflammasome Signaling and Bacterial Infections

Steffen Backert (Herausgeber)

Buch | Hardcover

XI, 282 Seiten

2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-41170-5 (ISBN)

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This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens ( Salmonella , Shigella , Yersinia , Listeria and Helicobacter ), respiratory pathogens ( Mycobacterium , Legionella , Burkholderia and Streptococcus ) as well as skin and soft tissue pathogens ( Francisella and Staphylococcus ). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic.

Steffen Backert is a professor at Erlangen/Nuremberg University (Germany), Chair of Microbiology.

General strategies in inflammasome biology (overview).- Structural mechanisms in inflammasome assembly and signaling.- Salmonella enterica inflammasome.- Yersinia pestis inflammasome.- Shigella flexneri inflammasome.- Helicobacter pylori inflammasome.- Listeria monocytogenes inflammasome.- Legionella pneumophila inflammasome.- Mycobacterium inflammasome.- Burkholderia pseudomallei inflammasome.- Streptococcus pneumoniae inflammasome.- Franciscella tularensis inflammasome.- Staphylococcus aureus inflammasome.

Erscheinungsdatum	08.10.2016
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XI, 282 p. 29 illus., 28 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Biomedical and Life Sciences • Burkholderia pseudomallei • Cytosolic bacteriolysis • Franciscella tularensis • Helicobacter pylori • Helicobacter pylori / Campylobacter pylori • Infectious Diseases • Inflammasome biology • Legionella pneumophila • Listeria monocytogenes • Medical Microbiology • Mycobacterium • NLR inflammasome • Parasitology • Pneumology/Respiratory System • Salmonella enterica • Shigella flexneri • Staphylococcus aureus • Streptococcus pneumoniae • Tumor immunotherapy • Yersinia Pestis
ISBN-10	3-319-41170-5 / 3319411705
ISBN-13	978-3-319-41170-5 / 9783319411705
Zustand	Neuware