Interleukin-27: Biological Properties and Clinical Application

Marek Jankowski, Tomasz Wandtke (Autoren)

Buch | Softcover

VI, 86 Seiten

2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-39662-0 (ISBN)

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This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

IL-27: Structure, Regulation and Variability.- IL-27: A Key Player in Immune Regulation.- IL-27 in Health and Disease.

Erscheinungsdatum	08.10.2016
Reihe/Serie	SpringerBriefs in Immunology
Illustrationen	Marta Jakubowska
Zusatzinfo	VI, 86 p. 5 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	atherosclerosis • Autoimmune disorders • Autoimmune uveitis • Biomedical and Life Sciences • Cancer • COPD • Cytokines and Growth Factors • Feto-maternal tolerance • IL-27 • immunology • immunotherapy • Infectious Diseases • inflammatory bowel disease • Interleukin-27 receptor • Multiple Sclerosis • Neoplastic diseases • Psoriasis • Rheumatoid Arthritis • Viral infections
ISBN-10	3-319-39662-5 / 3319396625
ISBN-13	978-3-319-39662-0 / 9783319396620
Zustand	Neuware