Drug Delivery Across Physiological Barriers

Buch | Hardcover

426 Seiten

2016
Pan Stanford Publishing Pte Ltd (Verlag)
978-981-4669-40-5 (ISBN)

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Transport of pharmaceutical agents in the body is paramount to therapeutic efficacy. Advances in the past decades have rendered a remarkable improvement of drug delivery strategies, which has helped to increase the bioavailability of therapeutic agents by protecting them from degradation, targeting them to diseased sites, and controlling their circulation time and release rate. Additionally, for most therapeutics, reaching the targets of action require penetration across tissues and/or entry within cells. The design of strategies to control the transport of therapeutic compounds through these physiological barriers has become an imperative and a challenging need in the quest for better therapeutics. This book provides an overview of the current advances in this field, including considerations on the biological regulation and natural mechanisms overcoming these barriers, as well as drug delivery strategies facilitating the transport of drugs and their carriers at the tissue, cell, and subcellular levels.

Silvia Muro is an associate professor in the Institute for Bioscience and Biotechnology Research and the Department of Bioengineering, University of Maryland, USA. She obtained her PhD in sciences (molecular biology) from Universidad Autónoma de Madrid, Spain. She received a postdoctoral training in drug delivery and obtained a research assistant professor position in the Pharmacology Department at the University of Pennsylvania, USA. Her research focuses on targeting and transport of nanomedicines into and across cells, with emphasis on delivery of biological therapeutics for treatment of inherited enzyme deficiencies. Her work has received awards from the Controlled Release Society, the American Society for Nanomedicine, and others, and since 2012 she is a standing member of the Nanotechnology Study Section [NANO] of the USA National Institute of Health.

Introduction. Physiological Barriers Controlling Penetration and Transport of Substances in the Body. Structure and function of epithelial and endothelial barriers. The plasma membrane as a semipermeable barrier. Biology and regulation of protein sorting and vesicular transport. Pathogens and intracellular transport. Strategies for Drug Penetration across Tissue Compartments. Drug transport across the skin. Mucosal barriers. Transport of therapeutics across the gastrointestinal epithelium. Crossing the endothelial barrier. Nanoparticle-based drug delivery to solid tumors. Drug Transport into Cells and Subsequent Intracellular Trafficking. Membrane lipids and drug transport. Drug delivery systems that fuse with the plasmalemma. Endocytosis and the endolysosomal route in drug delivery. Endo-lysosomal escape. Intracellular transport to the mitochondria and other organelles.

Erscheinungsdatum	10.10.2017
Zusatzinfo	51 Illustrations, black and white
Verlagsort	Singapore
Sprache	englisch
Maße	152 x 229 mm
Gewicht	738 g
Themenwelt	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie
	Technik ► Maschinenbau
	Technik ► Medizintechnik
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	981-4669-40-7 / 9814669407
ISBN-13	978-981-4669-40-5 / 9789814669405
Zustand	Neuware