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Helicobacter pylori VacA and Calcium Signalling in T-cells

How Helicobacter pylori evade immune response; An insight of VacA effects on intracellular calcium signalling in T-cells

Utkarsh Jain, Nidhi Chauhan (Autoren)

Buch | Softcover

128 Seiten

2015
Scholar's Press (Verlag)
978-3-639-86125-9 (ISBN)

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More than 50% of the world's population harbor Helicobacter pylori in their upper gastrointestinal tract. H. pylori persistently infects gastric mucosa and is associated with several diseases including peptic ulcer disease and gastric carcinoma. One of the most thoroughly studied virulence factors produced by H. pylori is the Vacuolating Cytotoxin A (VacA).The protein binds to the host cells and is internalized. Inside the host cells, it causes "vacuole"-like membrane vesicles in the cytoplasm of gastric epithelial cells. Besides vacuolation, VacA exerts various other effects on target cells. VacA also forms membrane-embedded pores at the inner-mitochondrial membrane, resulting in mitochondrial dysfunction by cytochrome c release and apoptosis induction. VacA suppresses nuclear translocation of nuclear factor of activated T-cells (NFAT) resulting in down regulation of interleukin-2 (IL2) gene transcription to efficiently block proliferation of T-cells. This book underlines the results showing involvement of VacA in the modulation of intracellular calcium signalling and therefore will provide new insights that are required to understand how VacA inhibits T-cell proliferation.

Utkarsh Jain was born & raised in India and further moved to Munich, Germany for his PhD thesis under the supervision of Prof. Rainer Haas at Max von Pettenkofer Institute. He was awarded Young Scientist Award - 2014 for his scientific contributions in gastric cancer causing bacteria Helicobacter pylori. He is now exploring his new research ideas.

Erscheinungsdatum	05.12.2015
Sprache	englisch
Maße	150 x 220 mm
Gewicht	207 g
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Helicobacter pylori • Helicobacter pylori / Campylobacter pylori
ISBN-10	3-639-86125-6 / 3639861256
ISBN-13	978-3-639-86125-9 / 9783639861259
Zustand	Neuware