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Myeloid-Derived Suppressor Cells and Cancer - David Escors, James E. Talmadge, Karine Breckpot, Jo A. Van Ginderachter, Grazyna Kochan

Myeloid-Derived Suppressor Cells and Cancer

Buch | Softcover
IX, 102 Seiten
2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-26819-4 (ISBN)
CHF 74,85 inkl. MwSt
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

Controversies in Neoplastic Myeloplasia.- Differentiation of Murine Myeloid-derived Suppressor Cells.- Human MDSCs.- Ex Vivo MDSC Differentiation Models.- Immunoregulatory myeloid cells in the tumor microenvironment.- Signal Transducer and Activation of Transcription 3: A Master Regulator of Myeloid-derived Suppressor Cells.- Future Perspectives.

Erscheinungsdatum
Reihe/Serie SpringerBriefs in Immunology
Zusatzinfo IX, 102 p. 8 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium Querschnittsbereiche Infektiologie / Immunologie
Naturwissenschaften Biologie Zellbiologie
Schlagworte Biomedical and Life Sciences • Cancer Research • Cell Biology • Ex vivo MDSC Differentiation • Human and Mouse MDSCs • immunology • Murine MDSC Differentiation • Myeloid-Derived Suppressor Cells (MDSCs) • Oncology • STAT3 Pathway • Therapeutic Targeting
ISBN-10 3-319-26819-8 / 3319268198
ISBN-13 978-3-319-26819-4 / 9783319268194
Zustand Neuware
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