Introduction to Molecular Vaccinology

Matthias Giese (Autor)

Buch | Softcover

XIX, 373 Seiten

2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-25830-0 (ISBN)

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This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines.The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

Matthias Giese has studied Molecular Biology and Biochemistry at the Saarland University/Germany. He got a first PhD in Immunology in the German Cancer Research Center/ Heidelberg. In 1994, after Matthias Giese has joined the pharmaceutical industry some years ago, his team in Vienna/ Austria started the first European multicenter clinical trial with a personalized genetic engineered anti-melanoma vaccine. Also Animal Health was interested in his expertise in modern vaccine technologies and so he changed the company and headed from now on a program on innovative vaccine approaches for the next years. His sabbatical leave from the industry was a return back to the academic roots. At Leipzig University/ Germany Matthias Giese got a major PhD (venia legendi) in Molecular Virology. Currently he is working again for the human pharmaceutical industry and additionally he teaches graduate students as associate professor. His focus is on neoantigenes, therapeutical vaccines, and the interaction with immune checkpoint modifiers as combination therapy. Matthias Giese is author and editor of “Molecular Vaccines – From Prophylaxis to Therapy” and an enthusiastic mountain marathon runner.

Part I: Scientific Bases.- From Pasteur to personalized vaccines.- Cell biology & Molecular Biology.- Basic vaccine immunology.- Gut and mucosa immunity.- Pediatric immunology.- Elderly immunology.- Tumor immunology.- Part II: Design of vaccines.- Antigen screening/selection processes.- Modes of action of vaccines.- Types of vaccines.- Adjutants.- Nanotechnologies.- Delivery technologies.- In silico vaccine design.- Infection vaccinology.- NINC vaccines.- Tumor vaccinology.- Vet vaccines.- Part III: Production and Public Health Issues.- Formulation.- Biomanufacturing.- Preclinical and clinical trials: basic principles.- Vaccine safety - assessment of adverse effects.- Ethical issues.- Registration process: Evidence-based vaccine trials.- Future vaccines.

Erscheinungsdatum	05.01.2016
Zusatzinfo	XIX, 373 p. 219 illus., 31 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	210 x 279 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	Biomedical and Life Sciences • immunology • Molecular Biology • Molecular Medicine • molecular vaccines • prophylaxis and therapy • Vaccine • Vaccine Design • vaccines
ISBN-10	3-319-25830-3 / 3319258303
ISBN-13	978-3-319-25830-0 / 9783319258300
Zustand	Neuware