Statistics in Toxicology Using R

Ludwig A. Hothorn (Autor)

Buch | Hardcover

234 Seiten

2015
Chapman & Hall/CRC (Verlag)
978-1-4987-0127-3 (ISBN)

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The apparent contradiction between statistical significance and biological relevance has diminished the value of statistical methods as a whole in toxicology. Moreover, recommendations for statistical analysis are imprecise in most toxicological guidelines. Addressing these dilemmas, Statistics in Toxicology Using R explains the statistical analysis of selected experimental data in toxicology and presents assay-specific suggestions, such as for the in vitro micronucleus assay.

Mostly focusing on hypothesis testing, the book covers standardized bioassays for chemicals, drugs, and environmental pollutants. It is organized according to selected toxicological assays, including:

Short-term repeated toxicity studies
Long-term carcinogenicity assays
Studies on reproductive toxicity
Mutagenicity assays
Toxicokinetic studies

The book also discusses proof of safety (particularly in ecotoxicological assays), toxicogenomics, the analysis of interlaboratory studies and the modeling of dose-response relationships for risk assessment. For each toxicological problem, the author describes the statistics involved, matching data example, R code, and outcomes and their interpretation. This approach allows you to select a certain bioassay, identify the specific data structure, run the R code with the data example, understand the test outcome and interpretation, and replace the data set with your own data and run again.

Ludwig A. Hothorn is a professor in the Institute of Biostatistics at the Leibniz University of Hannover. Dr. Hothorn has published more than 130 papers in peer-reviewed journals and contributed numerous book chapters. His research interests include computational statistics using R as well as the application of statistical methods in biology, agriculture, medicine, life sciences, toxicology, pharmacology, and quantitative genetics.

Principles. Simultaneous comparisons versus a negative control. Evaluation of long-term carcinogenicity assays. Evaluation of mutagenicity assays. Evaluation of reproductive toxicity assays. Ecotoxicology: Test on significant toxicity. Modeling of dose-response relationships. Further methods. Conclusions. Appendix.

Erscheinungsdatum	10.02.2016
Reihe/Serie	Chapman & Hall/CRC The R Series
Zusatzinfo	115 Tables, black and white; 98 Illustrations, black and white
Sprache	englisch
Maße	178 x 254 mm
Gewicht	660 g
Themenwelt	Mathematik / Informatik ► Mathematik ► Statistik
	Mathematik / Informatik ► Mathematik ► Wahrscheinlichkeit / Kombinatorik
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-4987-0127-2 / 1498701272
ISBN-13	978-1-4987-0127-3 / 9781498701273
Zustand	Neuware