Post-transcriptional Mechanisms in Endocrine Regulation

PhD Menon K.M.J., PhD Goldstrohm Aaron (Herausgeber)

Buch | Hardcover

XIV, 341 Seiten

2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-25122-6 (ISBN)

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This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.

K.M.J. Menon, PhD, is Professor in the Departments of Biological Chemistry & Obstetrics and Gynecology at the University of Michigan Medical School. Aaron C. Goldstrohm, PhD, is Associate Professor in the Department of Biological Chemistry at the University of Michigan Medical School.

Mechanisms of post-transcriptional gene regulation.- Post-transcriptional regulation of insulin and insulin like growth factor.- Posttranscriptional regulation of cytokine signaling during inflammatory responses.- Regulation of luteinizing hormone Receptor mRNA expression in the ovary.- Post-transcriptional regulation of steroid hormone receptors microRNA regulation of endocrine function in the ovary.- Translational control in the germline.- Post-transcriptional regulation of VEGF-A.- Post-transcriptional regulation of prostaglandin biosynthesis.- Translational and post-translational control of leptin production by fat cells.- Post-transcriptional regulation of parathyroid hormone gene expression in health and disease.- Post-transcriptional and post-translational regulation in steroidogenesis.- Post-transcriptional regulation of glucocorticoid function.- Post-transcriptional regulation by brain-derived neurotrophic factor in the nervous system.

Erscheinungsdatum	08.10.2016
Zusatzinfo	XIV, 341 p. 51 illus., 7 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	Biomedical and Life Sciences • cytokines • Endocrine Regulation • endocrinology • gene expression • hormones • Human Physiology • Insulin • Metabolism • microRNA • post-transcriptional • Post-transcriptional regulation • Post-translational regulation • steroid hormone receptor
ISBN-10	3-319-25122-8 / 3319251228
ISBN-13	978-3-319-25122-6 / 9783319251226
Zustand	Neuware