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Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing

Hamed Alborzinia (Autor)

Buch | Softcover

XIII, 153 Seiten

2015 | 2015
Springer Fachmedien Wiesbaden GmbH (Verlag)
978-3-658-10160-2 (ISBN)

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Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.

Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.

Drug Screening with New Perspectives.- Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip.- Anticancer Agents - Effects Measured in Real Time.- Metabolism of Cancer Cells.

Erscheint lt. Verlag	10.6.2015
Zusatzinfo	XIII, 153 p. 32 illus.
Verlagsort	Wiesbaden
Sprache	englisch
Maße	148 x 210 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	Biosensor Chip • Cancer Metabolism • chemotherapeutic drugs • Cisplatin • real-time analysis
ISBN-10	3-658-10160-1 / 3658101601
ISBN-13	978-3-658-10160-2 / 9783658101602
Zustand	Neuware