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Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) -

Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

Buch | Hardcover
395 Seiten
2015 | 1st ed. 2015
Springer (Verlag)
978-94-017-7196-2 (ISBN)
CHF 339,95 inkl. MwSt
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Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.

1 Clinical forms and animal models of hypophosphatasia.- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations.- 3 Genetically modified mice for studying TNAP function.- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis.- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex.- 6 TNAP in the retina.- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain.- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues?.- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells.- 10 Signal transduction pathways of TNAP: molecular network analyses.- 11 Vitamin B-6 Metabolism and Interactions with TNAP.- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex.- 13 TNAP and Pain Control.- 14 Neurological symptoms of Hypophosphatasia.- 15 Recombinant enzyme replacement therapy in hypophosphatasia.- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome.- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer’s disease in the focus.- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders.- Index

Erscheint lt. Verlag 7.8.2015
Reihe/Serie Subcellular Biochemistry ; 76
Zusatzinfo 37 Illustrations, color; 21 Illustrations, black and white; XXII, 395 p. 58 illus., 37 illus. in color.
Verlagsort Dordrecht
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Studium 1. Studienabschnitt (Vorklinik) Physiologie
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Zoologie
Schlagworte Brain Development • cerebral cortex • Epilepsy • Metabolic disorders • Neurobiology
ISBN-10 94-017-7196-0 / 9401771960
ISBN-13 978-94-017-7196-2 / 9789401771962
Zustand Neuware
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