Histone Deacetylase Inhibitors (HDIs)

Pharmacology, Uses & Health Effects

Buch | Hardcover

95 Seiten

2015
Nova Science Publishers Inc (Verlag)
978-1-63463-835-7 (ISBN)

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Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.

Preface; Classification & Function of Histone Deacetylase Inhibitors; Histone Deacetylase Inhibitors in the Treatment of Lymphoid Malignancies; Histone Deacetylase Inhibitors in the Treatment of Myeloid Malignancies; Histone Deacetylase Inhibitors for Breast Cancer: Driving Out of Stemness; Index.

Erscheint lt. Verlag	1.6.2015
Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	302 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-63463-835-2 / 1634638352
ISBN-13	978-1-63463-835-7 / 9781634638357
Zustand	Neuware