Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

Buch | Softcover

256 Seiten

2015
Springer (Verlag)
978-94-017-8202-9 (ISBN)

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The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Cytochrome P450 2E1 and its clinical aspects.- Nrf2 and antioxidant defense against CYP2E1 toxicity.- The role of Cytochrome P-4502E1 in ethanol-mediated carcinogenesis.- The Importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome.- Relevance of CYP2E1 to non-alcoholic fatty liver disease.- CYP2E1-catalyzed alcohol metabolism.- CYP2E1, oxidative stress, post-translational modifications and lipid metabolism.- The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system.

Erscheint lt. Verlag	7.3.2015
Reihe/Serie	Subcellular Biochemistry ; 67
Zusatzinfo	5 Illustrations, color; 32 Illustrations, black and white; XVI, 256 p. 37 illus., 5 illus. in color.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	94-017-8202-4 / 9401782024
ISBN-13	978-94-017-8202-9 / 9789401782029
Zustand	Neuware