Microglia in Health and Disease (eBook)

Amanda Sierra, Marie-Eve Tremblay (Herausgeber)

eBook Download: PDF

2014 | 2014
XIV, 486 Seiten
Springer New York (Verlag)
978-1-4939-1429-6 (ISBN)

Infos

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents.

To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

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These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Eve Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents.To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

Inhalt

The General Setting1. IntroductionAmanda Sierra and Marie-Ève Tremblay2. Historical ContextPayam Rezaie and Uwe-Karsten Hanisch3. Microglial PhysiologyJyoti J. Watters and Jennifer M. Pocock4. Lessons from in vivo ImagingDimitrios Davalos and Martin Fuhrmann5. Roles in Immune ResponsesRicha Hanamsagar, Sandra M. Cardona, Tammy Kielian, and Astrid E. Cardona6. Neuroprotection Versus NeurotoxicityKnut Biber and Michelle L. BlockWhat Is on StageThe New Roles7. Developmental Neuronal EliminationJosé L. Marín-Teva, Julio Navascués, Ana Sierra, and Michel Mallat     8. Developmental Angiogenesis, Myelination and AstrogliogenesisG. Jean Harry and Lorena Pont-Lezica9. Developing and Mature SynapsesMarie-Ève Tremblay, Rosa C. Paolicelli, Beth Stevens, Hiroaki Wake, and Alain Bessis10. Adult Neurogenesis, Learning and MemoryAmanda Sierra and Marie-Ève Tremblay                                           11. Neuropathic PainJessica K. Alexander, Simon Beggs, and Michael W. Salter               12. Drug AddictionXiaohui Wang, Thomas A. Cochran, Mark R. Hutchinson, Hang Yin, and Linda R. Watkins13. AgingRommy von Bernhardi, Betsi Flores, and Hiroshi NakanishiTheir Pathological ImplicationsCONDITIONS IMPACTING ON THE QUALITY OF LIFE14. Neurodevelopmental and Neuropsychiatric DisordersAkira Monji, Izumi Maezawa, Yoshito Mizoguchi, Takahiro A. Kato, and Lee-Way Jin15. Human Immunodeficiency VirusDaniel F. Marker, Shao-Ming Lu, and Harris A. Gelbard 16. Multiple SclerosisYoshifumi Sonobe and Akio SuzumuraLEADING CAUSES OF DEATH17. Ischemia and StrokeRaffaela Cipriani, Maria Domerq, and Carlos Matute                          18. Neurodegenerative DiseasesDiego Gómez-Nicola and Hugh Perry                                                19. Spinal Cord and Brain TraumaSamuel David and Phillip G. Popovich

Produkt-Details

• Erscheint lt. Verlag: 22.9.2014
• Zusatzinfo: XIV, 486 p. 32 illus., 20 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• Schlagworte: aging • Microglia • microglia and disease • microglia in health • Neural development
• ISBN-10: 1-4939-1429-4 / 1493914294
• ISBN-13: 978-1-4939-1429-6 / 9781493914296