Translation and Its Regulation in Cancer Biology and Medicine (eBook)
XXXIV, 697 Seiten
Springer Netherland (Verlag)
978-94-017-9078-9 (ISBN)
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development.
Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology.
The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.
The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development.Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology.The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.
Preface1 IntroductionPART I. TRANSALATION MACHINERY IN CANCER2 Mechanism of Translation in Eukaryotes3 Diverse Mechanisms of Translation Regulation and Their Role in Cancer4 eIF4E and Its Binding Proteins5 RNA Helicases and Their Cofactors6 PDCD47 eIF4G8 eIF39 The eIF2 Complex and eIF2α10 eIF5A11 eIF612 Translation Elongation13 Ribosomes14 Current and Emerging Therapies Targeting TranslationPART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER15 mTOR and Regulation of Translation16 Ribosomal Protein S6 and S6 Kinases17 eIF4E Phosphorylation Downstream of MAPK PathwayPART III. CELL FATE AND TRANSLATION IN CANCER18 Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells19 Translation and Apoptosis in Cancer20 Translation in Cancer at HypoxiaPART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES21 Melanoma and Non-Melanoma Skin Cancers22 Sarcomas23 Hematological Malignancies and Premalignant Conditions24 Brain Tumors25 Head and Neck Cancers26 Breast Cancer27 Cancers of the Respiratory System28 Gastric and Esophageal Cancers29 Colorectal Cancers30 Hepatic, Pancreatic and Biliary Cancers31 Pancreatic Neuroendocrine Tumors32 Gynecologic Cancers33 Prostate Cancer34 Cancers of the Urinary SystemList of Abbreviations
| Erscheint lt. Verlag | 13.10.2014 |
|---|---|
| Zusatzinfo | XXXIV, 697 p. 52 illus., 44 illus. in color. |
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Medizin / Pharmazie ► Studium | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Technik | |
| Schlagworte | Cancer • Cancer treatment and diagnostics • Protein synthesis • Signalling • Translation |
| ISBN-10 | 94-017-9078-7 / 9401790787 |
| ISBN-13 | 978-94-017-9078-9 / 9789401790789 |
| Haben Sie eine Frage zum Produkt? |
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