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Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

Hoa Huu Phuc Nguyen, M. Angela Cenci (Herausgeber)

Buch | Hardcover

XIII, 397 Seiten

2015 | 2015
Springer Berlin (Verlag)
978-3-662-46343-7 (ISBN)

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Motor dysfunction and cognitive impairment are major symptoms in both Huntington's Disease (HD) and Parkinson's Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.

Clinical Aspects of Huntington's Disease.- The Neuropathology of Huntington's Disease.- Neurobiology of Huntington's Disease.- Mouse Models of Huntington's Disease.- Transgenic Rat Models of Huntington's Disease.- Large Animal Models of Huntington's Disease.- Therapeutic Strategies for Huntington's Disease.- Clinical and Pathological Features of Parkinson's Disease.- Symptomatic Models of Parkinson's Disease and L-DOPA-Induced Dyskinesia in Non-human Primates.- Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?.- Viral Vector-Based Models of Parkinson's Disease.- Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits.- Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents.- Models of Multiple System Atrophy.

Erscheint lt. Verlag	9.6.2015
Reihe/Serie	Current Topics in Behavioral Neurosciences
Zusatzinfo	XIII, 397 p. 95 illus., 25 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Animal Models • Huntington • LRRK2 • Parkin • Pink-1 • Polyglutamine
ISBN-10	3-662-46343-1 / 3662463431
ISBN-13	978-3-662-46343-7 / 9783662463437
Zustand	Neuware