Gene Expression and Its Discontents

The Social Production of Chronic Disease

Rodrick Wallace, Deborah Wallace (Autoren)

Buch | Softcover

227 Seiten

2014 | 2010 ed.
Springer-Verlag New York Inc.
978-1-4899-8531-6 (ISBN)

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Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group, circumstances, the work suggests that epigenetic information sources act as analogs to a tunable catalyst, directing development into different characteristic pathways according to the structure of external signals. The results have significant implications for epigenetic epidemiology, in particular for understanding how environmental stressors, in a large sense, can induce a broad spectrum of developmental disorders in humans. The authors then apply the perspective to a number of chronic diseases broadly associated with obesity, using data at different scales of observation.

Models of development.- Groupoid symmetries.- Epigenetic catalysis.- Developmental disorders.- An interim perspective.- The obesity pandemic in the US.- Coronary heart disease in the US.- Cancer: a developmental perspective.- Autoimmune disorders.- Demoralization and obesity in Upper Manhattan.- Death at an early age: AIDS and related mortality in New York City.- Final thoughts.- Mathematical appendix.- References.

Erscheint lt. Verlag	29.11.2014
Zusatzinfo	IX, 227 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
	Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-4899-8531-X / 148998531X
ISBN-13	978-1-4899-8531-6 / 9781489985316
Zustand	Neuware