Antigens (eBook)

Volume II

Michael Sela (Herausgeber)

eBook Download: PDF

2014 | 1. Auflage
584 Seiten
Elsevier Science (Verlag)
978-1-4832-6955-9 (ISBN)

Infos

The Antigens, Volume II is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from protein antigens and blood group antigens to low molecular weight antigens and immunoglobulin A. The idiotypy of antibodies is also explored, along with the application of antibodies to the measurement of substances of physiological and pharmacological interest. Comprised of six chapters, this volume begins with a discussion on the molecular bases of antigenicity and immunogenicity of proteins, followed by a chapter dealing with blood group antigens. The immunologic effects of low molecular weight antigens are then considered, together with their elicitation of allergic reactions and their tolerance and specific inhibition of the immune response. The next chapter focuses on the use of antibodies to measure substances of physiological and pharmacological interest, with emphasis on the general principle of quantitative immunoassay. The book also analyzes the idiotypy of antibodies before concluding with a description of the antibody functions of immunoglobulin A. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Inhalt

Front Cover 1
The Antigens 4
Copyright Page 5
Table of Contents 8
Dedication 6
List of Contributors 12
Preface 14
Contents of Volume I 16
CHAPTER 1. Protein Antigens: The Molecular Bases of Antigenicity and 
18 
I. Introduction 18
II. Molecular Basis of Antigenicity 19
III. Molecular Basis of Immunogenicity 81
IV. Summary 87
References 89
CHAPTER 2. Blood Group Antigens 96
I. Introduction 97
II. Glycoprotein Antigen with ABH and Lewis Specificities 102
III. Glycosphingolipid Antigen with ABH and Lewis Specificities 115
IV. Immunogenetics and Biosynthesis of ABH and Lewis Antigens 124
V. Distribution of Blood Group Glycoproteins and Glycolipids 132
VI. Blood Group Substances in Malignant Cells and Tissues 136
VII. Chemistry of MN, P, I, J, and Rh Antigens 141
VIII. Addendum 149
Acknowledgments 150
References 150
CHAPTER 3. Low Molecular Weight Antigens 158
Abbreviations 159
I. Introduction 159
II. Immunogenicity 168
III. Elicitation of Allergic Reactions by Low MW Antigens 200
IV. Tolerance and Specific Inhibition of the Immune Response by Low MW Antigens 226
V. Further Special Uses of Low MW Antigens in Immunologie Research 237
VI. Conclusion and Summary 247
References 248
CHAPTER 4. 
 
 
266 
I. The General Principle in Quantitative Immunoassay 267
II. Detection Principles 270
III. Requirements of Antibody 272
IV. The Labeled Antigen 273
V. The Unlabeled Antigen 275
VI. Separation between Free and Bound Antigen 275
VII. Radioactive Labeling of Antibody 278
VIII. Validation of Radioimmunoassay 278
IX. Examples of the Application of General Principles of Immunoassay 279
X. Concluding Remarks 288
References 289
CHAPTER 5. Idiotypy of Antibodies 294
I. Introduction 295
II. The Technical Means of the Study of Idiotypy 299
III. Is Each Idiotypic Specificity Peculiar to Antibodies against a Given Antigen? 316

320 
V. What Is Known and What May Be Assumed about the Cellular Origin of Idiotypes 326
VI. Comparison of Idiotypy of the Antibodies Appearing in Different Individuals The Heterologous Reactions
VII. Comparison of Various Kinds of Antibodies Formed in One Individual against One Antigenic Material 341
VIII. Some of the Problems Raised by Idiotypy of Antibodies 369
IX. Summary 373
Acknowledgment 377
References 377
CHAPTER 6. Immunoglobulin A 382
Introduction 382
II. Distribution of IgA in the Animal Kingdom 386
III. Isolation and Quantitative Estimation of IgA 388
IV. Physicochemical Properties and Structure of IgA 401
V. Biosynthesis, Metabolism, and Distribution of IgA 458
VI. Antibody Functions of IgA 499
VII. IgA in Disease 508
References 518
Author Index 540
Subject Index 574

Produkt-Details

• Erscheint lt. Verlag: 10.5.2014
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie ► Anorganische Chemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 1-4832-6955-8 / 1483269558
• ISBN-13: 978-1-4832-6955-9 / 9781483269559