Erythropoietin and the Nervous System

Buch | Softcover

223 Seiten

2014 | 2006 ed.
Springer-Verlag New York Inc.
978-1-4899-7383-2 (ISBN)

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Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with relatively safety profile of this FDA-approved drug makes it an ideal candidate to take it into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This is the first book of its kind that brings together researchers from many different disciplines of neuroscience to review the current state-of-the-art in EPO and the nervous system. This book will benefit scientists and clinicians interested in neuroprotection in the broadest sense.

History and Biology of Erythropoietin in Hematopoietic and Non-Neural Tissues.- Expression of Erythropoietin and Its Receptor in the Central Nervous System.- Erythropoietin and Neuroprotection in the Central Nervous System: Intracellular Signaling Pathways.- Regulation of Erythropoietin Expression in the Nervous System: The Hypoxia Inducible Factor.- Erythropoietin Neuroprotection in the Term and Preterm Infant: Safety and Efficacy.- Erythropoietin for the Treatment of Acute Ischemic Stroke: Preclinical Rationale.- Erythropoietin Neuroprotection in the Retina.- Erythropoietin for Treatment of Human Brain Disease: Experience from Proof-of-Concept Trials.- Erythropoietin in Spinal Cord Injury.- Erythropoietin and Neuroprotection in the Peripheral Nervous System: In Vivo Studies.- An Endogenous Pathway Preventing Axonal Degeneration Mediated by Schwann Cell — Derived Erythropoietin.- Role of Erythropoietin in Inflammatory Pathologies of the CNS.- Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection.

Erscheint lt. Verlag	19.11.2014
Zusatzinfo	XI, 223 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Neurochirurgie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	1-4899-7383-4 / 1489973834
ISBN-13	978-1-4899-7383-2 / 9781489973832
Zustand	Neuware