Criteria (Dose/Effect Relationships) for Organochlorine Pesticides (eBook)

Report of a Working Group of Experts Prepared for the Commission of the European Communities, Directorate-General for Employment and Social Affairs, Health and Safety Directorate

M. Mercier (Autor)

eBook Download: PDF

2013 | 1. Auflage
398 Seiten
Elsevier Science (Verlag)
978-1-4831-3750-6 (ISBN)

Infos

Criteria (Dose/Effect Relationships) for Organochlorine Pesticides presents the effect of organochlorine compounds on the immunological processes. This book deals with several organochlorine pesticides. Organized into 15 chapters, this book begins with an overview of the properties and toxicology of dichlorodiphenyl trichloroethane (DDT), a potent non-systemic stomach and contact insecticide of high persistence on solid surface. This text then examines the absorption, metabolism, and excretion of lindane in laboratory animals and in humans as well. Other chapters consider the studies on the carcinogenic potential as well as the mutagenic effects of dieldrin. This book discusses as well the metabolism and pharmacokinetics of endrin, which is a non-systemic and persistent insecticide used primarily on field crops. The final chapter deals with the need for further evaluation of any possible long-term risks to humans from the production and use of the technical product. This book is a valuable resource for agriculturists and research workers.

Inhalt

Front Cover 1
Criteria (Dose/Effect Relationships) for Organochlorine Pesticides 
4 
Copyright Page 5
Table of Contents 6
Preface 10
Acknowledgements 12
Chapter I. DDT 18
Chemical and Physical Properties 18
Studies in Laboratory Animals 19
Toxic Effects in Animals 23
Subchronic and Chronic Effects 27
Mutagenic Effects 30
Carcinogenic Effects 34
Effects on Reproduction 40
Effects on Man 45
Chapter II. LINDANE (gamma-HCH) 60
Physical and Chemical Properties 60
Studies in Laboratory Animals 61
Toxic Effects in Animals 62
Subchronic and Chronic Effects 63
Mutagenic Effects 66
Carcinogenic Effects 67
Effects on Reproduction 68
Effects on Man 69
Conclusions 75
Chapter III. ALDRIN 76
Chemical and Physical Properties 76
Studies in Laboratory Animals 78
Toxic Effects in Animals 79
Subchronic and Chronic Effects 80
Mutagenic Effects 86
Carcinogenic Effects 86
Effects on Reproduction 88
Effects on Man 89
Conclusions 91
Chapter IV. DIELDRIN 92
Chemical and Physical Properties 92
Studies in Laboratory Animals 93
Toxic Effects in Animals 98
Subchronic and Chronic Effects 99
Mutagenic Effects 105
Carcinogenic Effects 105
Effects on Reproduction 109
Effects on Man 111
Conclusions 117
Chapter V. ENDRIN 118
Chemical and Physical Properties 118
Studies on Laboratory Animals 119
Subchronic and Chronic Effects 121
Effects on Reproduction 125
Mutagenic Effects 126
Carcinogenic Effects 127
Effects on Man 128
Conclusions 132
Chapter VI. HEPTACHLOR 134
Chemical and Physical Properties 134
Studies on Laboratory Animals 135
Toxic Effects in Animals 136
Sub-chronic and Chronic Effects 136
Carcinogenic Effects 139
Embryotoxic Effects 140
Effects on Man 141
Conclusions 142
Chapter VII. CHLORDANE 144
Chemical and Physical Properties 144
Studies in Laboratory Animals 145
Toxic Effects in Animals 146
Subchronic and Chronic Effects 147
Carcinogenic Effects 149
Effects on Reproduction 149
Effects on Man 152
Conclusions 153
Chapter VIII. HEXACHLOROBENZENE 154
Chemical and Physical Properties 154
Studies on Laboratory Animals 155
Toxic Effects in Animals 157
Subchronic and Chronic Effects 158
Mutagenic Effects 163
Carcinogenic Effects 163
Reproductive Effects 164
Embryotoxic Effects 164
Effects on Man 166
Residues in Food 169
Conclusions 171
Chapter IX. PENTACHLOROPHENOL 174
Chemical and Physical Properties 174
Studies on Laboratory Animals 176
Sub-chronic and Chronic Effects 181
Mutagenic Effects 183
Carcinogenic Effects 184
Embryotoxic Effects 184
Effects on Man 188
Conclusions 193
Chapter X. METHOXYCHLOR 194
Chemical and Physical Properties 194
Studies on Laboratory Animals 195
Subchronic and Chronic Effects 197
Mutagenic Effects 198
Carcinogenic Fffects 198
Embryotoxic Effects 200
Effects on Man 201
Residues in Food 202
Conclusions 203
Chapter XI. ENDOSULFAN 204
Chemical and Physical Properties 204
Studies in Laboratory Animals 205
Toxic Effects in Animals 207
Subchronic and Chronic Effects 208
Mutagenic Effects 209
Carcinogenic Effects 209
Embryotoxic Effects 210
Effects on Man 210
Residues in Food 211
Conclusions 213
Chapter XII. QUINTOZENE/PCNB 214
Chemical and Physical Properties 214
Studies on Laboratory Animals 215
Toxic Effects on Animals 218
Subchronic and Chronic Effects 219
Mutagenic Effects 220
Carcinogenic Effects 221
Embryotoxic Effects 223
Effects on Man 226
Residues in Food 226
Conclusions 227
Chapter XIII. MCPA, MCPB, MECOPROP AND DICHLORPROP 228
Chemical and Physical Properties 228
Studies in Laboratory Animals 231
Toxic Effects on Animals 233
Subchronic and Chronic Effects 234
Dichlorprop 236
Mutagenic Effects 236
Embryotoxic Effects 237
Effects on Man 237
Conclusions 239
Chapter XIV. 2,4-D 240
Chemical and Physical Properties 240
Studies in Laboratory Animals 241
Toxic Effects on Animals 245
Subchronic and Chronic Effects 246
Mutagenic Effects 249
Carcinogenic Effects 249
Embryotoxic Effects 250
Effects on Man 253
Conclusions 257
Chapter XV. 2,4,5-T 258
Chemical and Physical Properties 258
Studies of Laboratory Animals 259
Toxic Effects in Animals 262
Subchronic and Chronic Effects 263
Mutagenic Effects 264
Carcinogenic Effects 265
Embryotoxic Effects 267
Observations in Man 272
Conclusions 274
Bibliography 276
Appendix: 2,3,7,8-Tetrachlorodibenzo-p-Dioxin An Overview 344

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Weitere Fachgebiete ► Land- / Forstwirtschaft / Fischerei
• ISBN-10: 1-4831-3750-3 / 1483137503
• ISBN-13: 978-1-4831-3750-6 / 9781483137506