Opportunities and Challenges of the Therapies Targeting CNS Regeneration

H.D. Perez, B. Mitrovic, A. Baron Van Evercooren (Herausgeber)

Buch | Softcover

XIII, 186 Seiten

2014 | 2005
Springer Berlin (Verlag)
978-3-642-42148-8 (ISBN)

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The therapeutic options for the treatment of multiple sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer s, Parkinson s disease, etc. , have undergone enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the in?ammatory process (MS) and cl- sical neuroprotection (stroke, AD), therapeutic approaches focussing on active remyelinization and neuronal regeneration have become incre- ingly important. Based on current concepts, this book summarizes new therapeutic approaches. Although it was once thought that the central nervous system (CNS) of mammals was incapable of substantial recovery from injury, it is now clear that the adult CNS remains responsive to various substances that can promote cell survival and stimulate axonal growth. Among these substances are growth factors, including the neurotrophins and cytokines. Stem cell therapies for the induction of remyelinization and neuroregeneration are reviewed. The potential role of a protective - munity in the induction of remyelination and neuroregeneration is also discussed. Different gene therapy approaches for the treatment of MS VI Preface and other neurodegenerative diseases such as Alzheimer s disease and spinal cord injury, etc. , are also summarized.

New Strategies for CNS Repair.- Heterogeneity of Multiple Sclerosis: Implications for Therapy Targeting Regeneration.- The Neuroprotective Effect of Inflammation: Implications for the Therapy of Multiple Sclerosis.- Fibroblast Growth Factors in Oligodendrocyte Physiology and Myelin Repair.- White Matter Progenitor Cells Reside in an Oligodendrogenic Niche.- At the Interface of the Immune System and the Nervous System: How Neuroinflammation Modulates the Fate of Neural Progenitors In Vivo.- Remyelination and Restoration of Axonal Function by Glial Cell Transplantation.- Gene and Stem Cell Therapy for Autoimmune Demyelination.- Novel Gene Therapeutic Strategies for Neurodegenerative Diseases.- Measuring Injury and Repair of Myelin and Neurons in Multiple Sclerosis.

Erscheint lt. Verlag	21.10.2014
Reihe/Serie	Ernst Schering Foundation Symposium Proceedings
Zusatzinfo	XIII, 186 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	326 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	central nervous system • Multiple Sclerosis • nervous system • neurodegenerative diseases • Neuroinflammation • neurons • Parkinson • Physiology • Stemm Cell Therapy • Transplantation
ISBN-10	3-642-42148-2 / 3642421482
ISBN-13	978-3-642-42148-8 / 9783642421488
Zustand	Neuware