Nanoparticulate Vaccine Delivery Systems

Buch | Hardcover

244 Seiten

2015
Pan Stanford Publishing Pte Ltd (Verlag)
978-981-4613-30-9 (ISBN)

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Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formulation process. Also, multiple antigens, targeting ligands, and adjuvants can all be encapsulated within the same particle. When administered orally, these particles are designed to withstand the acidic environment of the stomach and are targeted to Peyer’s patches and the gut-associated mucosal immune system. Since these vaccines are particulate in nature, they are readily taken up by phagocytic antigen-presenting cells, such as M cells, dendritic cells, and macrophages in Peyer’s patches of the intestines, resulting in a strong immune response and antibody production. Since no needles are required for oral vaccines, this method of vaccine delivery is inexpensive and suitable for mass vaccination in the developing world as well as the developed world. This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, human papillomavirus, and hepatitis B. It also discusses recent studies on vaccines for cancers such as melanoma and ovarian, breast, and prostate cancer.

Martin J. D’Souza is professor and director of Graduate Programs, College of Pharmacy, Mercer University, USA, co-director of the Center for Drug Delivery, and director of the Mercer Clinical Laboratory. He has published more than 90 articles in various journals and authored several book chapters and holds four patents. Prof. D’Souza’s research interests are in vaccines for infectious diseases and cancer.

Introduction to Particulate Vaccine. Methods of Preparation of Nanoparticulate Vaccines. DOE. Routes of Administration. Case Studies. Meningitis Vaccine. TB Oral Vaccine. Cancer Vaccines. Influenza Vaccine. Melanoma Vaccine. Ovarian Cancer Oral Vaccine. Breast Cancer Oral Immunotherapy. Prostate Cancer Vaccine for Oral Delivery. Future Trends in Vaccine Delivery.

Zusatzinfo	19 Illustrations, color; 61 Illustrations, black and white
Verlagsort	Singapore
Sprache	englisch
Maße	174 x 246 mm
Gewicht	476 g
Themenwelt	Medizin / Pharmazie ► Pflege
	Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	981-4613-30-4 / 9814613304
ISBN-13	978-981-4613-30-9 / 9789814613309
Zustand	Neuware