Blood Clotting Enzymology (eBook)

Walter H. Seegers (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
640 Seiten
Elsevier Science (Verlag)
978-1-4832-2545-6 (ISBN)

Infos

Blood Clotting Enzymology covers the mechanisms of blood clotting and their role in thrombosis, hemostasis, and many associated ramifications. This book is composed of 12 chapters that consider the integration of knowledge on blood clotting enzymology with hemostasis physiology. The opening chapter deals with the enzymology of the sol-gel transformation was studied in terms of proteins, fats, carbohydrates, surface physics, immunology, biophysical mechanisms, structural architecture, vitamin K and its antagonists, and the rheology of the blood. The subsequent chapters review the biophysical properties and composition of active substance in blood coagulation, as well as the concepts of prothrombin activation. These topics are followed by discussions on the chemical and physicochemical properties of fibrinogen and fibrin; the application of immulogical methods to delineate important properties of plasma constituents; and the mechanisms of antithrombin activity. Other chapters tackle the importance of hirudin and cobra venom for certain experimental laboratory work in the study of the physiology of blood coagulation. The final chapters survey the role of platelets in hemostasis, bleeding disorders, and the chemistry and function of vitamin K in blood coagulation. This book will prove useful to hematologists, enzyme scientist, immunologists, and research workers who are interested in blood coagulation mechanisms.

Inhalt

Front Cover 1
Blood Clotting Enzymology 4
Copyright Page 5
Table of Contents 10
List of Contributors 6
Preface 8
Chapter 1. Use and Regulation of the Blood Clotting Mechanisms 14
I. Introduction 14
II. Blood Vessel Wall Dynamics 15
III. Platelet Function 15
IV. Autoregulation in Hemostasis 17
V. Blood Coagulation 18
VI. Prothrombin Activation 20
VII. Complexity of Metabolic Integration 26
VIII. Summary 31
References 32
Chapter 2. Molecular Characteristics of Substances Active in Blood Coagulation 36
I. Introduction 37
II. Assay for Clotting and for Enzyme Activities 38
III. Bovine Prothrombin 39
IV. Human Prothrombin 50
V. Prothrombin of Other Species 50
VI. Bovine Thrombin 51
VII. Human Thrombin 65
VIII. Bovine Autoprothrombin C 68
IX. Bovine Prethrombin 72
X. Bovine Autoprothrombin III 74
XI. Bovine Autoprothrombins Ip and Ic 78
XII. Autoprothrombin II 79
XIII. Fibrinogen 80
XIV. Fibrin Stabilizing Factor 84
XV. Hageman Factor 85
XVI. Accelerator Globulin 88
XVII. Platelet Cofactor I (Factor VIII) 90
XVIII. Plasma Thromboplastin Antecedent 92
XIX. Antithrombins 93
XX. Inhibitor Source Material 94
XXI. Substance P from Urine 95
XXII. Factor VII, Factor IX, and Factor X 95
XXIII. Platelet Factors 96
XXIV. Tissue Procoagulants 96
XXV. Lipid Procoagulants 99
XXVI. Summary 100
References 104
Chapter 3. Activation of Prothrombin 116
I. Introduction 117
II. Activation in Strong Salt Solutions 119
III. Activation in Strong Salt Solutions: Summary 126
IV. Activation of Prothrombin with Protamine Sulfate, and Polarized Surface Layers 127
V. Activation Characteristics of Prethrombin and Auto pro thrombin III 128
VI. Formation and Significance of Intermediate Prothrombin Activation Products 131
VII. Development of Fibrinogenolytic and Esterolytic Activities from Prothrombin 137
VIII. Dependence of Thrombin Yield on the Limited Procoagulant or Anticoagulant 138
IX. Function of Ac-Globulin and Lipids 142
X. Prothrombin in Plasma 143
XI. Two-stage Analysis Refractory State and Regeneration of Sensitivity to Two-stage Analytical Reagents 147
XII. Summary 148
ACKNOWLEDGMENT 150
References 150
Chapter 4. Fibrinogen to Fibrin Transformation 156
I. Early History of the Fibrinogen-Fibrin Transformation with Emphasis on Limited Proteolysis 156
II. Current Concept of the Limited Proteolysis in the Fibrinogen-Fibrin Transformation 159
III. Fibrinogen and Fibrin at the Molecular Level 199
References 221
Chapter 5. Immunochemistry 230
I. Introduction 231
II. Prothrombin and Its Derivatives 232
III. Accelerator Globulin (Factor V) 260
IV. Platelet Cofactor I (Factor VIII) 264
V. Platelet Factor 3 265
VI. Fibrinogen and Related Molecules 271
VII. Conclusion 285
ACKNOWLEDGEMENT 287
References 287
Chapter 6. Surface Activity in Blood Coagulation 292
I. Introduction 292
II. Contact 293
III. The Initiation of Clotting in Vivo 323
IV. The Evolution of Contact Factor 326
V. Summary and Certain Conclusions 328
References 329
Chapter 7. Antithrombin 336
I. Historical Background 336
II. Methods of Measurement 338
III. Preparation of Antithrombin Fractions 340
IV. Action of Antithrombin 346
V. Summary 355
ACKNOWLEDGMENTS 356
References 356
Chapter 8. Plasma Anticoagulants or Inhibitors 358
I. Introduction 358
II. Natural Anticoagulants 360
III. Artificial Anticoagulants 377
IV. Summary 384
References 386
Chapter 9. Platelets in Hemostasis 392
I. Description of Capillary Function in Thrombocytopenia 393
II. Thrombopoietic Aspects of Platelets 393
III. Platelet Functions 399
IV. Metabolism of Platelets 421
V. Platelet Preservation 426
VI. Immunological Aspects of Platelets 426
VII. Platelet Transfusion 427
VIII. Summary 428
References 429
Chapter 10. Irregular Blood Coagulation 434
I. Introduction 434
II. Inherited Bleeding Disorders 436
III. Acquired Bleeding Disorders 466
IV. Summary 484
References 488
Chapter 11. Ultras tructure of the Fibrin Clot 500
I. Introduction 501
II. Specific Aims 502
III. Normal Fibrin Formation 502
IV. Abnormal Fibrin Formation 525
V. Conclusions 558
References 558
Chapter 12. Chemistry and Function of Vitamin K 564
I. Introduction 564
II. Chemistry of the K Vitamins 565
III. Detection and Determination 567
IV. Occurrence 570
V. Structural Specificity of Vitamin K Action 572
VI. Metabolism 574
VII. Vitamin K-II (S) 585
References 586
AUTHOR INDEX 590
SUBJECT INDEX 617

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• ISBN-10: 1-4832-2545-3 / 1483225453
• ISBN-13: 978-1-4832-2545-6 / 9781483225456