Microdialysis in Drug Development

Buch | Softcover

340 Seiten

2014
Springer-Verlag New York Inc.
978-1-4899-9621-3 (ISBN)

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A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.

Prof. Markus Müller, MD is Head of the Department of Clinical Pharmacology at the Medical University of Vienna in Austria. He is specialized in Internal Medicine and Clinical Pharmacology and is an international expert in clinical research. He has published over 80 articles on the use and methodology of microdialysis in clinical drug development.

Introduction to the Microdialysis Technology.- Recovery and Calibration Techniques: Toward Quantitative Microdialysis.- Analytical Considerations for Microdialysis Sampling.- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective.- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations.- Microdialysis in Antibiotic Research.- Skin and Transdermal Drug Delivery: Advantages and Challenges.- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis.- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease.- Microdialysis in Pain Research.- Microdialysis in Ocular Drug Development.- Microdialysis in Metabolic Research.- High Molecular Weight Targets and Treatments Using Microdialysis.- Complementary Techniques – Positron Emission Tomography.- Open Flow Microperfusion: An Alternative Method to Microdialysis?.- Microdialysis in Internal Organs and Tumors.

Reihe/Serie	AAPS Advances in the Pharmaceutical Sciences Series ; 4
Zusatzinfo	XII, 340 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Chemie ► Technische Chemie
	Technik
ISBN-10	1-4899-9621-4 / 1489996214
ISBN-13	978-1-4899-9621-3 / 9781489996213
Zustand	Neuware