Oral Delivery of Macromolecular Drugs

Barriers, Strategies and Future Trends

Buch | Softcover

242 Seiten

2014 | 2009 ed.
Springer-Verlag New York Inc.
978-1-4899-8282-7 (ISBN)

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Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could be dosed via the oral route. Given this, the successful oral delivery of macromolecular drugs presents an enormous opportunity. Oral Delivery of Macromolecular Drugs will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected.

Andreas Bernkop-Schnürch is the Dean of the Faculty of Chemistry and Pharmacy and Professor of Pharmaceutical Technology at the University of Innsbruck, Austria. His main interests focus on non-invasive drug delivery systems, multifunctional polymers such as thiomers, mucoadhesion and permeation enhancement. He is author of more than 200 original research and review articles and received the Research-Award of the City of Vienna (Vienna), EURAND-Award (Boston), Best of Biotech Award (Vienna), MBPW-Award (Munich), PHÖNIX Award (Mannheim), Houska-Award (Vienna) and Austrian-Nanoaward (Vienna). In addition, Andreas Bernkop-Schnürch is founder and owner of the following companies: ThioMatrix GmbH, Dr. K. Schnürch KG and Green River Polymers GmbH.

Enzymatic Barriers.- Gastrointestinal Mucus Gel Barrier.- The Absorption Barrier.- Strategies to Overcome the Enzymatic Barrier.- Low Molecular Mass Permeation Enhancers in Oral Delivery of Macromolecular Drugs.- Polymeric Permeation Enhancers.- Strategies to Overcome Efflux Pumps.- Multifunctional Polymeric Excipients in Oral Macromolecular Drug Delivery.- Nano- and Microparticles in Oral Delivery of Macromolecular Drugs.- Liposome-Based Mucoadhesive Formulations for Oral Delivery of Macromolecules.- Strategies in Oral Immunization.- Oral Delivery of Nucleic Acid Drugs.

Erscheint lt. Verlag	8.10.2014
Zusatzinfo	XIII, 242 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-4899-8282-5 / 1489982825
ISBN-13	978-1-4899-8282-7 / 9781489982827
Zustand	Neuware