Biochemistry of Pulmonary Emphysema
Seiten
1992
Springer Berlin (Hersteller)
978-3-540-19775-1 (ISBN)
Springer Berlin (Hersteller)
978-3-540-19775-1 (ISBN)
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An examination of pulmonary emphysema, a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis in the lung. The text reviews natural inhibitors and proteinases at a biochemical level.
Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for re-establishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.
Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for re-establishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.
Pulmonary emphysema - what's going on; elastin and the lung; an introduction to the endopeptidases; lung proteinase and emphysema; multiple functions of neutrophil proteinases and their inhibitor complexes; kinetics of the interaction of human leucocyte elastase with protein substrates; proteinase inhibitor candidates for therapy of enzyme-inhibitor imbalances; antileucoprotease (secretory leucocyte proteinase inhibitor), a major proteinase inhibitor in the human lung; development and evaluation of antiproteases as drugs for preventing emphysema; genetic control of human alpha-1-antitrypson and hepatic gene therapy; neutrophils, neutrophil elastase and the fragile lung.
| Vorwort | R. Corsico |
|---|---|
| Zusatzinfo | 41 figs., 26 tabs. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Gewicht | 665 g |
| Einbandart | gebunden |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Pneumologie |
| Naturwissenschaften ► Biologie ► Biochemie | |
| ISBN-10 | 3-540-19775-3 / 3540197753 |
| ISBN-13 | 978-3-540-19775-1 / 9783540197751 |
| Zustand | Neuware |
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